… mechanisms of drug interactions, additional pharmacokinetic … of pharmacogenetics on the
clinical significance of interactions. … database in clinical practice because of the differences …

… Metabolomics has a major role in clinical practice as it represents >95% of the workload in
… clarify the clinical significance of DNA variants thought to be pathogenic. It also identified …

… clinical trials focusing on a specific drug provide sufficient evidence that the drug is safe and
efficacious, it can be approved for use … and become adopted in clinical practice. Of greater …

… The market size of personalized medicine is expected to reach USD 87.7 billion by the
year … Herein, we review the application of WES genomic information in clinical practice. The …

… possible, paving the way to Personalized Medicine (PM) [4]. … into clinical practice, to stratify
patients according to their … related to drug metabolism, which has been implicated in many …

… clinical acceptance, we examine additional barriers to and facilitators of HTS application to
personalized medicine… can present considerable storage and maintenance implications [108]. …

… In brief, the implications for clinical practice are based on a list of four criteria … : the clinical
effect associated with the gene–drug interaction, the level of evidence supporting the clinical …

… in the clinical management of patients with mCRC in the emerging era of precision medicine.
… algorithm for mCRC is based, although it does not completely represent the complexity of …

… work highlights key breakthroughs in the development of enabling technologies that further
the goal of personalized and precision medicine, … in realizing truly individualized patient care. …

… Our framework identifies novel drug-microbiome interactions … be used in drug development
and personalized medicine. … , specifically as it relates to drug interactions, while accounting …