Circulating cell adhesion molecules in metabolically healthy obesity

A Mulhem, Y Moulla, N Klöting, T Ebert… - … journal of obesity, 2021 - nature.com
… For example, E-selectin mediates the first adhesion step of … In this study of 3.5 million men
and women from the United … CAMs, may be upregulated in patients with obesity depending on …

Cardiovascular risk factors and molecular routes underlying endothelial dysfunction: Novel opportunities for primary prevention

G Benincasa, E Coscioni, C Napoli - Biochemical Pharmacology, 2022 - Elsevier
… and novel molecular routes driving early endothelial dysfunction … may restore endothelial
function via upregulation of eNOS gene … of adhesion molecules, such as vascular cell adhesion

Effect of bariatric surgery on inflammation and endothelial dysfunction as processes underlying subclinical atherosclerosis in morbid obesity

J Carmona-Maurici, E Cuello, D Ricart-Jané… - Surgery for Obesity and …, 2020 - Elsevier
… of endothelial dysfunction, might be useful in assessing early … MO could upregulate the
expression of adhesion molecules [… of all 4 endothelial cell adhesion molecules measured in this …

Potential role of circulating endoglin in hypertension via the upregulated expression of BMP4

E Gallardo-Vara, L Gamella-Pozuelo, L Perez-Roque… - Cells, 2020 - mdpi.com
… , we analyzed the protein secretome of human endothelial … wild type with male sEng + mice,
hypertension appeared 18 … cells (HUVECs) were purchased from Lonza and used at early

Microvascular Endothelial Dysfunction in Human Obesity: Role of TNF-α

A Virdis, R Colucci, N Bernardini… - The Journal of …, 2019 - academic.oup.com
earliest manifestation of CV disease in obesity is endothelial … of adhesion molecule expression
by the endothelial and smooth … The upregulated production of ET-1 in obesity might result …

Inflammatory mechanisms contributing to endothelial dysfunction

P Theofilis, M Sagris, E Oikonomou, AS Antonopoulos… - Biomedicines, 2021 - mdpi.com
hypertension, diabetes mellitus (DM), smoking, and obesity. … , with downstream upregulation
of target genes of adhesion molecules (… Last but not least, MCP-1 has been the first reported …

Mineralocorticoid and estrogen receptors in endothelial cells coordinately regulate microvascular function in obese female mice

LA Biwer, BV Carvajal, Q Lu, JJ Man, IZ Jaffe - Hypertension, 2021 - Am Heart Assoc
… mRNA and protein expression is upregulated when EC-MR is … antihypertensive, but this
study and others provide a rationale for earlier use of MR antagonism to maintain endothelial

Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation

J Totoń-Żurańska, TP Mikolajczyk, B Saju… - Clinical …, 2024 - portlandpress.com
… cell adhesion molecule 1; VEGF, vascular endothelial growth … Endothelial cells serve as
first-line players that respond to … Up-regulation of factor Tcf21 promotes the transformation of …

Early programming of adult systemic essential hypertension

V Guarner-Lans, A Ramírez-Higuera… - … Journal of Molecular …, 2020 - mdpi.com
… Renal denervation prevents hypertension in male offspring … cardiovascular complications of
diabetes and obesity. In addition, … of eNOS [173]; HDAC1 upregulation in ECs leads to eNOS …

Soluble (pro) renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor

Z Fu, F Wang, X Liu, J Hu, J Su, X Lu, A Lu… - Clinical …, 2021 - portlandpress.com
… Here, we report for the first time that … adhesion molecules eg, IL-6, IL-8, VCAM-1 and ICAM-1
[15], we were prompted to determine whether sPRR-His evokes inflammation and adhesion