Genetic variation of glycophorins and infectious disease

EJ Hollox, S Louzada - Immunogenetics, 2023 - Springer
gene conversion events from sequence read mis-mapping. … A functional study suggested
that an allele at GYPC encoding … a major agent of natural selection in humans who live where …

Nutrition and its role in human evolution

WPT James, RJ Johnson, JR Speakman… - Journal of internal …, 2019 - Wiley Online Library
… Indeed, gene conversion provides a basis for evolution and … malaria by altering sequences
of glycophorin A and B, which … can be eliminated by natural selection. This system in …

Genome structural variation in human evolution

EJ Hollox, LW Zuccherato, S Tucci - Trends in Genetics, 2022 - cell.com
evolving neutrally, with selection having no effect on the allele frequency. Early studies on
SVs in humans … allowing extensive gain of copy number of olfactory receptor genes encoding

Gene tree species tree reconciliation with gene conversion

D Hasić, E Tannier - Journal of mathematical biology, 2019 - Springer
… based on dynamic programming become ineffective. We propose here a novel mathematical
framework including gene conversion as an evolutionary event in gene tree/species tree …

Structural variation of the malaria-associated human glycophorin ABE region

S Louzada, W Algady, E Weyell, LW Zuccherato… - BMC genomics, 2020 - Springer
gene dosage effect. It is known that DUP4 results in a GYPB-GYPA fusion gene that codes
… , suggesting a history of gene conversion events between the glycophorin repeat regions (…

Identifying adaptive alleles in the human genome: from selection mapping to functional validation

EA Werren, O Garcia, AW Bigham - Human genetics, 2021 - Springer
… acknowledge the impact of this major Eurocentric bias in the current map of natural selection
in humans, … for population geneticists, human geneticists, and molecular anthropologists. …

Host genetics and infectious disease: new tools, insights and translational opportunities

AJ Kwok, A Mentzer, JC Knight - Nature Reviews Genetics, 2021 - nature.com
… locus neighbouring glycophorin genes (encoding erythrocyte … translational impact,
polymorphisms in the gene encodingnatural selection. For example, for cholera, targets of …

[HTML][HTML] Few Plasmodium falciparum merozoite ligand and erythrocyte receptor pairs show evidence of balancing selection

LI Ochola-Oyier, K Wamae, I Omedo, C Ogola… - … , Genetics and Evolution, 2019 - Elsevier
impact of malaria on human evolution is evident from the signatures of selection in genes
encoding erythrocyte proteins in humanGenetic variation in the glycophorins, in particular Gyp …

Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects

D Damena, A Denis, L Golassa, ER Chimusa - BMC medical genomics, 2019 - Springer
… variants such as cluster of the glycophorin genes (GYPA/B/E) … hits in none protein coding
regulatory regions (regulatory SNPs) … genome; the majority of which have effects too small to be …

Genomic structural variation: A complex but important driver of human evolution

DC Soto, JM Uribe‐Salazar, CJ Shew… - American Journal of …, 2023 - Wiley Online Library
… played a role in natural selection, and (3) the role of gene duplications in … IGC Interlocus
gene conversion … CNVs of coding regions can directly impact gene dosage, while SVs of …