… , and the potential for therapeutic targeting of IL-1β-induced disruption of the intestinal TJ
barrier to prevent or treat intestinal inflammation. In summary, IL-1β is markedly elevated in …

… intestinal inflammation, consisting of HT-29 colon epithelial cells stimulated with cytokines
relevant in the context of intestinal inflammation … a significant intestinal anti-inflammatory effect …

… Intestinal epithelial tight junction (TJ) barrier dysfunction has been implicated as an …
factor of various inflammatory conditions of the gut, including inflammatory bowel disease (IBD), …

… epithelia tight junction integrity. Given that excessive colonic inflammation could cause
dysfunctional tight junction, … whether STAT6 directly regulated epithelial tight junction proteins and …

… epithelial TJ barrier or a leaky gut is an important pathogenic factor that … of intestinal
inflammation in inflammatory bowel disease (IBD) and other inflammatory conditions of the gut, …

… Schematic presentation of healthy and leaky gut. Epithelial tight junctions are intact in a
healthy gut and selectively lets some molecules in and out of the intestinal epithelium by …

… Tight junctions (TJs) play an important role in intestinal … in intestinal epithelial cells are
composed of different junctional … in the intestine results in systemic and intestinal inflammation and …

… increased tight junctions and reduced intestinal epithelium permeability as well. Taken
together, our data suggest that vitamin A regulates the tight junction function to limit inflammation …

… epithelial barrier during inflammation, only homoectoine completely prevented the inflammatory
claudin switch in tight junctions… Thus, homoectoine may serve as diet supplement in IBD …

… toll-like receptors that are expressed by the intestinal epithelium. In particular, bacterial-… of
intestinal tight junctions. Given that ingested prebiotics are robust modulators of the intestinal …