JI Weitz, NC Chan - Blood, The Journal of the American Society …, 2020 - ashpublications.org
… VTE treatment, bleeding remains the major side effect, particularly in cancer patients. Factor XII and factorXI have … and apixaban in the Factor XIa Inhibition for the Prevention of Venous …
… to determine the incidence of deep-veinthrombosis after surgery. In such patients, … factorXI levels or postoperative factorXIinhibition with intravenous abelacimab, a factorXI–…
A Greco, C Laudani, M Spagnolo, F Agnello, DC Faro… - Circulation, 2023 - Am Heart Assoc
… , by preventing the adoption of an effective antithrombotic strategy). Inhibition of factorXI (FXI) … In most cases of arterial and venousthrombosis, FXI is activated by thrombin resulting from …
… factorXI antisense oligonucleotides were successful in lowering factorXI levels and preventing … Whether this result is confirmed with oral or long-acting parenteral factorXIinhibitors in …
C Hsu, E Hutt, DM Bloomfield, D Gailani… - Journal of the American …, 2021 - jacc.org
… would provide opportunities for treatment of a wider range of … to which factorXIinhibitors attenuate thrombosis without … underlying mechanism of venousthromboembolism (VTE) and …
C Kearon, SR Kahn - Blood, The Journal of the American …, 2020 - ashpublications.org
The most important decision in the long-term treatment of venousthromboembolism (VTE) is how long to anticoagulate. VTE provoked by a reversible risk factor, or a first unprovoked …
… This article (1) reviews the rationale for the development of factorXIinhibitors, (2) identifies … Ir-CPI attenuated arterial and venousthrombosis in murine models,[20] prolonged the time …
R Chopard, IE Albertsen, G Piazza - Jama, 2020 - jamanetwork.com
… June 2020 for randomized clinical trials, meta-analyses, systematic reviews, and observational studies. Risk factors for venousthromboembolism (VTE), such as older age, malignancy (…
Z Zhai, C Li, Y Chen, G Gerotziafas… - Thrombosis and …, 2020 - thieme-connect.com
… Concomitant venousthromboembolism (VTE), a potential cause of unexplained deaths, has been frequently reported in COVID-19 cases, but its management is still challenging due to …