Genetic and phenotypic landscape of the major histocompatibilty complex region in the Japanese population
… 106 complex human diseases and quantitative traits extracted … patterns of connections (Fig.
5b). In the former, several tight … Phase-defined HLA gene analysis was also used to resolve …
5b). In the former, several tight … Phase-defined HLA gene analysis was also used to resolve …
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese
… -expression quantitative trait loci (eQTL)-associated genes in 7 … genetic correlation between
this study and 67 complex … and BMI confirmed by our genetic analysis is consistent with the …
this study and 67 complex … and BMI confirmed by our genetic analysis is consistent with the …
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population
… quantitative trait locus (cis-eQTL) variants in LD with type 2 … complex human traits (32
diseases and 59 quantitative traits) … agreement with the observations from our genetic analysis. …
diseases and 59 quantitative traits) … agreement with the observations from our genetic analysis. …
A cross-population atlas of genetic associations for 220 human phenotypes
… of GWASs in the Japanese population, we identified 519 … European dataset across binary
and quantitative traits (Methods). … of human complex traits in terms of populations and scope of …
and quantitative traits (Methods). … of human complex traits in terms of populations and scope of …
GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits
… of the FFQ on the genetic analysis of dietary habits. Second, … the largest genetic cohorts in
Japan, it is difficult currently to … function for binominal or quantitative traits, respectively. Age, …
Japan, it is difficult currently to … function for binominal or quantitative traits, respectively. Age, …
GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architecture
… summary data for 51 diseases and 58 quantitative traits in … , only a candidate gene study
has detected the association … To filter out regions with complex patterns of LD, we specified …
has detected the association … To filter out regions with complex patterns of LD, we specified …
Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements
… variation of diverse polygenic diseases and quantitative traits… identified 38 complex traits
whose genetic variation regulates … and serum samples from 12 medical institutions in Japan. …
whose genetic variation regulates … and serum samples from 12 medical institutions in Japan. …
Clinical use of current polygenic risk scores may exacerbate health disparities
… PRS, which predict complex traits on the basis of genetic data… First, the power to discover
an association in a genetic study … /populations and disease endpoints versus quantitative traits…
an association in a genetic study … /populations and disease endpoints versus quantitative traits…
Characterizing rare and low-frequency height-associated variants in the Japanese population
… in our previous GWASs for quantitative traits in the BBJ 15,16 . … will reveal the biological link
of FATP genes with the regulation of height. … of diverse populations in complex trait genetics. …
of FATP genes with the regulation of height. … of diverse populations in complex trait genetics. …
Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction
… Since the genetic architecture is different according to trait 33 , the PRS differences need to
… of complex human traits. To this end, we performed GWASs of 45 quantitative traits on the …
… of complex human traits. To this end, we performed GWASs of 45 quantitative traits on the …