Cell type-specific epigenetic links to schizophrenia risk in the brain

I Mendizabal, S Berto, N Usui, K Toriumi, P Chatterjee… - Genome biology, 2019 - Springer
… , including novel information from a major yet relatively underexplored brain cell population
(… Moreover, we show that schizophrenia-associated DNA methylation changes reduce the …

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease

J Bryois, NG Skene, TF Hansen, LJA Kogelman… - … genetics, 2020 - nature.com
… 24 brain cell types, 4 types of neuron were consistently associated with schizophrenia 11 .
cell-type associations for schizophrenia and intelligence was due to the second explanation. …

The three-dimensional landscape of the genome in human brain tissue unveils regulatory mechanisms leading to schizophrenia risk

W Mah, H Won - Schizophrenia research, 2020 - Elsevier
genes across brain development and in different brain cell … comparison between
schizophrenia risk genes identified in … underlying shared genetic basis of psychiatric disorders. …

Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain

E Radulescu, AE Jaffe, RE Straub, Q Chen… - Molecular …, 2020 - nature.com
… study was to identify and prioritize co-expressed gene sets in a … and with polygenic risk for
schizophrenia. Weighted … The logic behind this approach is that functional gene assemblies …

Cell type-specific manifestations of cortical thickness heterogeneity in schizophrenia

MA Di Biase, MP Geaghan, WR Reay, J Seidlitz… - Molecular …, 2022 - nature.com
… in schizophrenia relates to interregional variation in distinct neural cell types, as inferred
from established gene … cellular processes underlying CTh alterations across individuals with …

Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes

SE Morgan, J Seidlitz, KJ Whitaker… - Proceedings of the …, 2019 - National Acad Sciences
… biological mechanisms underlying schizophrenia are still unclear. We shed light on structural
brain differences in psychosis using an … Risk genes identified by the largest extant GWAS of …

[HTML][HTML] Endophenotypes in schizophrenia: digging deeper to identify genetic mechanisms

TA Greenwood, A Shutes-David… - … of psychiatry and brain …, 2019 - ncbi.nlm.nih.gov
… into the underlying neurobiology that they provide may ultimately reveal the underlying
genetic … Ingenuity Pathway Analysis of the genes identified through association and linkage …

What genes are differentially expressed in individuals with schizophrenia? A systematic review

AK Merikangas, M Shelly, A Knighton, N Kotler… - Molecular …, 2022 - nature.com
… through which genes exert their influence on the etiology of schizophrenia. Although these
… of methodology will facilitate the identification of the role of genes underlying schizophrenia. …

[PDF][PDF] Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functions

SB Thyme, LM Pieper, EH Li, S Pandey, Y Wang… - Cell, 2019 - cell.com
… the mechanisms underlying polygenic illnesses such as schizophrenia and … identify the in
vivo functions of many associated genes; such analysis could also prioritize candidate genes

Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders

J Bryois, D Calini, W Macnair, L Foo, E Urich… - Nature …, 2022 - nature.com
… (PD) 22,23 , schizophrenia (SCZ) 24 and multiple sclerosis (MS) 25 potentially act through
… are active and putative genetic variants underlying risk loci for four major brain disorders. …