Participation bias in the UK Biobank distorts genetic associations and downstream analyses

T Schoeler, D Speed, E Porcu, N Pirastu… - Nature Human …, 2023 - nature.com
… To evaluate the impact of selective participation, here we derived UK Biobank participation
… the UK Biobank and a representative sample. We then conducted weighted genome-wide

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

I Tachmazidou, K Hatzikotoulas, L Southam… - … genetics, 2019 - nature.com
… We calculated the genome-wide genetic correlation between each of the osteoarthritis
definitions and all available 832 human traits and diseases (accessed 15–18 June, 2018). Of …

A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank

W Meng, BW Chan, C Harris, MB Freidin… - … molecular genetics, 2020 - academic.oup.com
… We defined neck or shoulder pain cases and controls based on the responses by UK
Biobank participants to a specific pain question. This question focused on neck or shoulder pain …

Fine-scale population structure in the UK Biobank: implications for genome-wide association studies

JP Cook, A Mahajan, AP Morris - Human Molecular Genetics, 2020 - academic.oup.com
UK Biobank. To do this, we first used LD-score regression (21) to assess the genome-wide
genetic … ), and selected traits available in the UK Biobank. We utilized published association …

Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort

XR Gao, H Huang, H Kim - Human molecular genetics, 2019 - academic.oup.com
… For this analysis, we used the genetic data from the March 2018 release. Genotype calling,
imputation and quality control (eg filtering variants based on Hardy–Weinberg equilibrium …

Whole-genome sequencing of half-a-million UK Biobank participants

UK Biobank Whole-Genome Sequencing Consortium… - medRxiv, 2023 - medrxiv.org
… Here, we report on whole-genome sequencing of 490,640 UK Biobank participants, …
Genome-wide association analysis of the UK Biobank phenome Genome-wide association analysis …

Genetic predictors of participation in optional components of UK Biobank

J Tyrrell, J Zheng, R Beaumont, K Hinton… - Nature …, 2021 - nature.com
Genome-wide genetic correlations do not provide evidence … These likely properties of
genome-wide genetic correlations … (eg, the ALSPAC versus UK Biobank comparison), or, when …

Analyses of biomarker traits in diverse UK biobank participants identify associations missed by European-centric analysis strategies

Q Sun, M Graff, B Rowland, J Wen, L Huang… - … of human genetics, 2022 - nature.com
… Here, we conducted genome-wide association studies (GWAS) of 31 serum and urine …
Asian (n = 9823) ancestry UK Biobank (UKBB) participants. We adjusted for all known GWAS …

[PDF][PDF] Genome-wide association study of cancer risk in UK Biobank

K Burrows, P Haycock, C Bull, T Dudding… - University of …, 2021 - data.bris.ac.uk
… This document describes genome-wide association studies (GWAS) of pan-cancer and
site-specific cancers in UK Biobank participants. The UK Biobank is a population-based cohort …

Rare variant contribution to human disease in 281,104 UK Biobank exomes

Q Wang, RS Dhindsa, K Carss, AR Harper, A Nag… - Nature, 2021 - nature.com
Genome-wide association studies have uncovered thousands of … The UK Biobank contains
detailed phenotypic data linked to medical records for approximately 500,000 participants, …