Impact and diagnostic gaps of comprehensive genomic profiling in real-world clinical practice

AP Singh, E Shum, L Rajdev, H Cheng, S Goel… - Cancers, 2020 - mdpi.com
non-small cell lung cancer (NSCLC) and extended-RAS for colorectal … of advanced NSCLC
patients treated in the community setting identified gaps in national guideline based genomic

[HTML][HTML] Genomic testing among patients with newly diagnosed advanced non-small cell lung cancer in the United States: A contemporary clinical practice patterns …

L Paz-Ares, A Gondos, D Saldana, M Thomas… - Lung Cancer, 2022 - Elsevier
genomic profiling [CGP]) and non-NGS-based genomic testing … therapy options (<4 genes
tested with no positive results). … , reflecting the community oncology care setting in the US. …

[HTML][HTML] Clinical outcomes for plasma-based comprehensive genomic profiling versus standard-of-Care tissue testing in advanced nonsmall cell lung cancer

RD Page, LM Drusbosky, H Dada, VM Raymond… - Clinical lung cancer, 2022 - Elsevier
… outcomes based on plasma-based comprehensive genomic profiling are comparable to
published targeted therapy outcomes with tissue profiling, even in community-based centers. …

Non-small cell lung cancer from genomics to therapeutics: A framework for community practice integration to arrive at personalized therapy strategies

S Rajurkar, I Mambetsariev, R Pharaon… - Journal of Clinical …, 2020 - mdpi.com
… therapies in lung cancer, to report the gaps in community practice … with cancer are treated
in the community setting and 50% of collaborative group trial accruals occur in the community […

… and Opportunities of the Implementation of Comprehensive Genomic Profiling in Everyday Clinical Practice with Non-Small Cell Lung Cancer: National Results from …

D Čerina, K Krpina, M Jakopović, N Dedić Plavetić… - Cancers, 2023 - mdpi.com
… , the introduction of comprehensive genomic profiling (CGP) in … genomic profiling in NSCLC.
The results have shown the utility and potential benefit of comprehensive genomic profiling, …

[HTML][HTML] Clinical impact for advanced non-small-cell lung cancer patients tested using comprehensive genomic profiling at a large USA health care system

R Meng, AK Dowdell, A Vita, D Hanes, B Bapat… - ESMO Real World Data …, 2024 - Elsevier
… testing program for NSCLC in a community-based health care setting that may be of utility
to … our diverse health system are most affected by gaps in access to testing and or precision …

Impact of clinical practice gaps on the implementation of personalized medicine in advanced nonsmall-cell lung cancer

H Sadik, D Pritchard, DM Keeling, F Policht… - JCO Precision …, 2022 - ascopubs.org
gaps associated with diagnostic testing-informed personalized medicine strategies on the
treatment of advanced nonsmall-cell lung cancer … checkpoint inhibitors from genetic testing to …

… -world biomarker testing patterns in patients with metastatic non-squamous non-small cell lung cancer (NSCLC) in a US community-based oncology practice setting

AN Sireci, PM Krein, LM Hess, T Khan, J Willey… - Clinical Lung Cancer, 2023 - Elsevier
… of molecularly defined somatic genomic alterations or driver … , particularly in the community
setting. In a retrospective chart … effort to evaluate any remaining gaps in care for future study. …

Real-world clinical outcomes after genomic profiling of circulating tumor DNA in patients with previously treated advanced non-small cell lung cancer

S Olsen, J Liao, H Hayashi - Current Oncology, 2022 - mdpi.com
… and community settings. The claims data are provided by a commercial agreement with a
data aggregator (the ‘parent dataset’), which collates high-quality industry-standard sources of …

Budget impact analysis of comprehensive genomic profiling in patients with advanced non-small cell lung cancer

J Signorovitch, Z Zhou, J Ryan, R Anhorn… - Journal of Medical …, 2019 - Taylor & Francis
… and 12-month survival in NSCLC in community oncology settingsCitation 40 , there were
notable gaps between the identification of alterations and use of treatments informed by those …