… Glycogen synthase kinase 3β gene polymorphisms may be associated with bipolar I disorder
… Haplotype analysis of GSK-3β gene polymorphisms in bipolar disorder lithium responders …

… In conclusion, GSK-3β may be a susceptibility gene for … depression and bipolar disorder,
and genetic epidemiology … ) support overlapping genetic factors between the two diseases. …

… polymorphism (SNP) rs17026688 in GADL1 has been found to be associated with lithium
response in bipolar I (BPI… , which might not be related with bipolar disorder or lithium drug use. …

… This may not be that surprising since bipolar disorder associated risk genes such as SHANK2
and … There are two single-nucleotide polymorphisms (SNPs) in the CREB1 gene that are …

… injury, major depressive disorder and bipolar disorder. Further, … disorders may differ, we
hypothesize that these pathways … Further, specific polymorphisms in the GSK-3 promoter have …

… gene polymorphisms have previously been associated with BD, … Bipolar disorder alone and
together with MetS, may cause … Therefore, further investigation on genes associated with the …

… that could play a role in the pathogenesis of bipolar disorders. … between glycogen synthase
kinase-3 gene polymorphism … [9] Glycogen synthase kinase-3 is a proapoptotic peptide and …

… , here we posit that GSK-3 may act as a central convergence point and … genes encoding
proteins involved in regulating the function of GSK-3 have shown polymorphisms associated …

… genetic studies have found that single-nucleotide polymorphisms (SNPs) in the GSK-3β gene
… executive functions in patients with bipolar disorder, which may be achieved by inhibiting …

… glycogen synthase kinase-3 (GSK3), a primary target for lithium, the first line therapy for BD
(Beaulieu, 2012). Common genetic variation in AKT1 was first reported to be associated … can …