[HTML][HTML] Cellular origins of regenerating liver and hepatocellular carcinoma

Á Holczbauer, KJ Wangensteen, S Shin - JHEP Reports, 2022 - Elsevier
population of hepatic progenitor cells, which are associated with the canals of Hering and
bile … This study found significant differences in the repopulation capacity of hepatocytes from …

[HTML][HTML] Liver progenitor cell-driven liver regeneration

J So, A Kim, SH Lee, D Shin - Experimental & Molecular Medicine, 2020 - nature.com
… , but its regenerative capacity is compromised in severe liver … dedifferentiation of biliary
epithelial cells or hepatocytes into … the LPC population by undergoing metaplasia in chronic liver

Liver regeneration: Cellular origin and molecular mechanisms

R Huang, X Zhang, J Gracia‐Sancho… - Liver …, 2022 - Wiley Online Library
… of liver progenitor cells (LPCs) during liver regeneration. Oval … capacity to differentiate into
hepatocytes and bile duct cells … in vitro cultivation, liver repopulation assay and lineage tracing…

[HTML][HTML] Bipotent transitional liver progenitor cells contribute to liver regeneration

W Pu, H Zhu, M Zhang, M Pikiolek, C Ercan, J Li… - Nature …, 2023 - nature.com
… and bile ducts of cirrhotic livers (Extended Data Fig. 6d). … this LPC population to be transitional
liver progenitor cells (TLPCs). … To evaluate the potential ability of proliferation for each cell, …

Liver progenitors and adult cell plasticity in hepatic injury and repair: knowns and unknowns

S Ko, JO Russell, LM Molina… - Annual Review of …, 2020 - annualreviews.org
biliary epithelial cells themselves may serve as facultative … and refuting the existence of liver
progenitor cells in a variety of … capacity of fetal liver and the livers of lower vertebrates. The …

Hepatic progenitor cells and biliary tree stem cells

G Carpino, S Morini, S Carotti, E Gaudio - Liver Diseases: A …, 2020 - Springer
bile ducts contain a population of stem/progenitor cells collectively named biliary tree
stem/progenitor cells (… organs, showed clonal expansion capability and are multipotent since they …

Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche

D Willnow, U Benary, A Margineanu, ML Vignola… - Nature, 2021 - nature.com
population size of three cell types, namely the bipotent endoderm progenitor (BEP) cells,
LV progenitor cells and PB progenitor … the ability to undergo hepatic, pancreatic or biliary

[HTML][HTML] Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease

JM Hallett, S Ferreira-Gonzalez, TY Man, AM Kilpatrick… - Cell stem cell, 2022 - cell.com
… We have therefore purified human biliary epithelial cells (hBECs) from human livers that
were not used for … Hepatic progenitor cells of biliary origin with liver repopulation capacity. …

[HTML][HTML] Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

T Katsuda, J Matsuzaki, T Yamaguchi, Y Yamada… - Elife, 2019 - elifesciences.org
cells likely arose from non-hepatic cells, such as biliary epithelial cells (BECs) or so-called
liver epithelial cells, the origins … The capacity to repopulate injured livers is the most important …

[PDF][PDF] Cholangiocyte‐to‐Hepatocyte Differentiation: A Context‐Dependent Process and an Opportunity for Regenerative Medicine

MJ Perugorria, P Olaizola, JM Banales - Hepatology, 2019 - Wiley Online Library
… injury and impaired hepatocyte proliferation, as well as their long-term liver repopulation
capacity. This study … Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nat …