… of gene regulation to … highly specific epigenetic silencing of endogenous genes. The SID
causes the recruitment of histone deacetylases via interaction with the transcriptional repressor …

… elements (CREs), yet functional analysis of gene-distal … -based epigenetic editing in
developmental gene regulation and… the combinations of independent repressors (LSD1 and KRAB …

… Here, we systematically interrogated the cis regulatory features that … repressors (KRAB-dCas9
or Ezh2-dCas9) and DNA methyltransferases (DNMT3A-dCas9 + DNMT3L) were very …

… either silenced or overexpressed imprinted genes. Canonical … protein fused to a repressor
domain, silencing the target gene. … of epigenome regulation. Therefore, the current research of …

… , used in gene regulation and epigenome editing, to the dCas9 … an improved dCas9-based
repressor consisting of two repression … The system demonstrated superior gene silencing in …

… a gene editing innovation, CRISPR/Cas9 technology provides … Moreover, epigenetic silencing
of CRISPRoff is not limited to … [80] used CRISPR epigenome editing technology to regulate …

… Generation of CRISPR/Cas9 knockout mutants for the candidate genes and inheritance of
the edits We used the CRISPR/Cas9 gene-editing system to investigate the roles in the melon …

… –p300 complex to distal non-regulatory genomic regions … transcriptional activators and
repressors have been fused to … with imaging functionality of CRISPR/Cas9 will create a novel …

… or edit epigenetic marks when directed to regulatory regions by the gRNA 32 . We employed
dCas9 to direct the transcriptional repressor … silenced in CNS neurons by epigenetic editing …

… systems, we then discuss how epigenome editing could be implemented in combination …
repressor domain and the DNMT methyltransferase fused to the dCas9 ensured stable silencing …