Cornering an Ever-Evolving Coronavirus: TATX-03, a fully human synergistic multi-antibody cocktail targeting the SARS-CoV-2 Spike Protein with in vivo efficacy

I Roodink, M van Erp, A Li, S Potter… - bioRxiv, 2021 - biorxiv.org
SARS-CoV-2 infection with resistance to mutagenic escape. … -existing human scFv repertoires,
reactive to a broad range of … (two monoclonal antibodies, and two two-Ab combination

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

X Tian, C Li, A Huang, S Xia, S Lu, Z Shi… - Emerging microbes & …, 2020 - Taylor & Francis
… first time that a SARS-CoV-specific human monoclonal antibody, CR3022, could … Human
monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape

[HTML][HTML] Neutralizing monoclonal antibodies for COVID-19 treatment and prevention

JP Jaworski - biomedical journal, 2021 - Elsevier
combination of nMAbs accounting for different specificities may provide a powerful way to
minimize mutational escape by … the S protein could confer a synergistic neutralizing effect. Anti-…

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

D Pinto, YJ Park, M Beltramello, AC Walls, MA Tortorici… - Nature, 2020 - nature.com
monoclonal antibodies that target the S glycoprotein of SARS-… escape mutants. These results
pave the way for using S309 and … A synergistic effect between two non-competing anti-RBD …

Emerging antibody-based therapeutics against SARS-CoV-2 during the global pandemic

Y Sun, M Ho - Antibody therapeutics, 2020 - academic.oup.com
… , 13 human monoclonal antibodies targeting the SARS-CoV-2 … against resistance due to
virus escape mutants. Besides the … wild-type SARS-CoV-2 virus in a synergistic manner (67). …

Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

Z Ku, X Xie, E Davidson, X Ye, H Su… - Nature …, 2021 - nature.com
… potent neutralizing monoclonal antibodies (mAbs) targeting … combination of CoV2-06 and
CoV2-14 showed a synergy in … Then, antibody alone or in mixture were twofold diluted to cover

[HTML][HTML] SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies

MG Cox, TP Peacock, WT Harvey, J Hughes… - Nature Reviews …, 2023 - nature.com
synergistic effects among RBD mutations lead to enhanced resistance when they are present
in combination… , as well as its epidemic characteristics and immune and vaccine escape. …

Broad sarbecovirus neutralization by a human monoclonal antibody

MA Tortorici, N Czudnochowski, TN Starr, R Marzi… - Nature, 2021 - nature.com
… all SARS-CoV-2 variants of concern), and an escape profile that is … be used in combination
with other site I or site IV mAbs to … Data were analysed using MacSynergy II and synergy plots …

Perspectives on the development of neutralizing antibodies against SARS-CoV-2

M Ho - Antibody therapeutics, 2020 - academic.oup.com
… A recent report showed that none of the monoclonal antibodies isolated from SARS-CoV-2 …
Mutations in the virus can lead to escape variants [38]. Multiple strategies and combination

[HTML][HTML] Mutational escape prevention by combination of four neutralizing antibodies that target RBD conserved regions and stem helix

H Tang, Y Ke, Y Liao, Y Bian, Y Yuan, Z Wang, L Yang… - Virologica Sinica, 2022 - Elsevier
monoclonal antibody (mAb) 2G1 from prototypic SARS-CoV-2 … cocktails to maintain coverage
against emerging variants … a synergistic effect to delay the generation of escape variants, …