Construction of disulfide containing redox-responsive polymeric nanomedicine

S Fu, CM Rempson, V Puche, B Zhao, F Zhang - Methods, 2022 - Elsevier
… polymeric nanoparticle with shell or core crosslinked disulfide … widely investigated as drug
delivery platforms due to many … as drug carriers, where hydrophobic cores can be used as …

Redox-sensitive nanoscale drug delivery systems for cancer treatment

E Mirhadi, M Mashreghi, MF Maleki… - International journal of …, 2020 - Elsevier
disulfide bond by GSH, L-cysteine, dithiothreitol (DTT), or tris (2 carboxyethyl) phosphine (TCEP)
leads to the removal of hydrophilicHigh sensitivity of thioketal linkages to ROS makes …

Recent advances in the redox-responsive drug delivery nanoplatforms: A chemical structure and physical property perspective

S Mollazadeh, M Mackiewicz… - Materials Science and …, 2021 - Elsevier
… Se single bond ) has high sensitivity to low concentrations of the … reported hydrophobic
cysteine-based poly (disulfide amide) … inorganic nanoparticles provide a convenient platform for …

Pyridyl disulfide functionalized polymers as nanotherapeutic platforms

B Sui, C Cheng, P Xu - Advanced Therapeutics, 2019 - Wiley Online Library
… More importantly, the redox-sensitive disulfide bond … copolymer was further attached with
cysteine-modified melittin, which … , these nanoparticles could encapsulate hydrophobic guest …

Cysteine-based redox-responsive nanoparticles for fibroblast-targeted drug delivery in the treatment of myocardial infarction

X Ji, Y Meng, Q Wang, T Tong, Z Liu, J Lin, B Li, Y Wei… - ACS …, 2023 - ACS Publications
… (GSH)-responsive nanoparticle platform capable of targeted … PF543-NPs, a redox nonsensitive,
disulfide bond-free amino acid … GSH-responsive NPs, Cys-based NPs have hydrophobic

Redox‐responsive self‐assembled nanoparticles for cancer therapy

D Li, R Zhang, G Liu, Y Kang… - Advanced healthcare …, 2020 - Wiley Online Library
… scavenge ROS based on the sulfhydryl group on cysteine, which … have attached hydrophilic
PEG and hydrophobic poly(lactic-… , so they are extremely sensitive under redox conditions. Of …

Poly (disulfide) s: from synthesis to drug delivery

R Zhang, T Nie, Y Fang, H Huang, J Wu - Biomacromolecules, 2021 - ACS Publications
… in the construction of poly(disulfide) platforms to inspire new … a hydrophobic l-cysteine-based
poly(disulfide amide) (Cys-… of disulfide bonds into the backbones for cytosolic redox-…

Disulfide-mediated bioconjugation: disulfide formation and restructuring on the surface of nanomanufactured (microfluidics) nanoparticles

M Geven, H Luo, D Koo, G Panambur… - … applied materials & …, 2019 - ACS Publications
… eg, peptides, where a cysteine is flanked by cationic residues… PEG chains to bridge between
hydrophobic domains, thereby … by the well-known high sensitivity of DLS to larger particles …

A drug/carrier dual redox-responsive system based on 6-mercaptopurine dimer-loaded cysteine polymer nanoparticles for enhanced lymphoma therapy

L Wang, C Dai, Y Fang, X You, J Wu - Nano Research, 2022 - Springer
… prepared a cysteine-based poly (disulfide amide) with redox-… with the poly (disulfide amide)
to form dual redox-responsive … loaded into nanoparticles (NPs) owing to its hydrophobicity, …

Ultrasensitive redox-responsive porphyrin-based polymeric nanoparticles for enhanced photodynamic therapy

Y Xue, J Tian, L Xu, Z Liu, Y Shen, W Zhang - European Polymer Journal, 2019 - Elsevier
… exhibit a somewhat hydrophobic property and forceful … disulfide linkage-based polymeric
nanoparticle platforms have been … Disulfide-containing nanoparticles with high sensitivity and …