… is defined by increased systemic inflammatory cytokines (for … ; at low concentration, IL-1
inhibits voltage-gated calcium … lung response to intrauterine inflammation is partly mediated …

… and inflammatory pathways involved in chorioamnionitis followed by a brief discussion of the
neonatal complications and management of chorioamnionitis. … IL-1 signaling mediates the …

… increases in inflammatory mediators including IL-1 in patients … systemic inflammatory response
syndrome (SIRS). Other … “mild” chorioamnionitis from the “severe” chorioamnionitis, and …

… response was partially controlled by IL-1 or TNFα signaling, but the frequency of CD4+FoxP3+
did not recover after blockade IL-1 … mediated regulatory mechanisms to limit inflammatory …

… -1 (IL-1) system has been consistently associated with pregnancy complications such as
preterm birth, including chorioamnionitis, … The IL-1 system has been targeted in several animal …

… to chorioamnionitis triggering IL-1 production, ia injection of IL-1 was shown to induce sterile
chorioamnionitis … , and is speculated to be mediated in part by IL-1 (Table 1), however this …

… Our results demonstrated the key role of IL-1 in driving GBS-induced chorioamnionitis through
(i) upregulating pro-inflammatory … IL-1 Mediates Pulmonary and Systemic Inflammatory …

… is meant to mimic chorioamnionitis levels of inflammation in the fetal lung. Lung appears to
be … increase of immune cells that would respond to chorioamnionitis and we show MAIT cells …

… agents will cause a systemic inflammatory response. In mice, … CXCL8 and CSF3 in an
IL-1-dependent manner (84). … endocrine system that may modulate inflammation-mediated …

… a systemic inflammatory response, frequently a result of the activation of the innate limb of the
immune response… Pathologic evidence of a systemic fetal inflammatory response indicates …