… Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages, …

… genome-wide association studies have recently identified many loci that influence key human
ageing traits, including lifespan… the genetic factors driving this variability in ageing between …

… We were able to detect significant genetic associations at two previously identified
longevity/lifespan-related loci, FOXO3 and CDKN2A/B. For the other loci, we did not find evidence for …

… studies offers the possibility of developing measurements that can identify successful (biological)
aging … relationships among factors associated with extremely long life likely account for …

… Next, we assumed there is a group of genetic factors, … associated with parental longevity,
a proxy for lifespan, in ref. . … Modern large population studies involve prospective cohorts and …

… on Medicine has identified 12 key SDOH risk factors from 5 … factors will likely have cumulative
effects over the lifespan influencing health span, quality of life in old age, and longevity itself…

… A long and healthy life is determined by many different factors… suggest the genetic components
of both human lifespan (ie … we identify have previously been shown to influence lifespan …

… individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from
genome-wide association … and its shared genetic contributions with lifestyle factors and longevity. …

… research focuses on measuring the pace of aging to identify … is too expensive for large
population studies, and this method … diseases, healthspan, and longevity in humans has not been …

… With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging are …