[图书][B] A computational study of cisplatin and its derivatives towards the analysis, improvement and design of anticancer agents

PS Pole - 2021 - search.proquest.com
… to further understand properties such as the chemical reactivity, kinetic stability, and reactivity
descriptors that can further elaborate why some compounds are active against cancer cells…

[HTML][HTML] Experimental and in silico analysis of cordycepin and its derivatives as endometrial cancer treatment

P Fong, CN Ao, KI Tou, KM Huang, CC Cheong… - Oncology …, 2019 - ncbi.nlm.nih.gov
The aim of this study was to investigate the inhibition effects of cordycepin and its derivatives
on endometrial cancer cell growth. Cytotoxicity MTT assays, clonogenic assays, and flow …

Mathematical model predicts response to chemotherapy in advanced non-resectable non-small cell lung cancer patients treated with platinum-based doublet

E Kozłowska, R Suwiński, M Giglok… - PLoS Computational …, 2020 - journals.plos.org
… with platinum doublet[11]. Here, we focus on the platinum doublet palliative treatment of
non-small cell lung carcinoma. Mathematical models could contribute to personalized cancer

Genotyping, in silico screening and molecular dynamics simulation of SNPs of MGMT and ERCC1 gene in lung cancer patients treated with platinum-based doublet …

S Singh, A Gupta, N Singh, PS Sengupta… - Journal of …, 2023 - Taylor & Francis
Full article: Genotyping, in silico screening and molecular dynamics simulation of SNPs of
MGMT and ERCC1 gene in lung cancer patients treated with platinum-based doublet

Efficacy of CDK4/6 inhibitors in preclinical models of malignant pleural mesothelioma

E Aliagas, A Alay, M Martínez-Iniesta… - … Journal of Cancer, 2021 - nature.com
… After 26 days of treatment, we quantified the macrophages … of mice compared with
cisplatin-based chemotherapy or vehicle; … after standard chemotherapy doublet treatment. Finally, …

Cisplatin-based Liposomal Nanocarriers for Drug Delivery in Lung Cancer Therapy: Recent Progress and Future Outlooks

K Mohammad-Jafari, SM Naghib… - Current …, 2024 - ingentaconnect.com
… The antitumor efficacy of the combination was assessed in vivo … , and enhance the anticancer
impact on lung cancer [133]. For … as a first-line doublet chemotherapy option by the NCCN …

From tumour perfusion to drug delivery and clinical translation of in silico cancer models

M Hadjicharalambous, PA Wijeratne, V Vavourakis - Methods, 2021 - Elsevier
… of the efficacy of cisplatin-based doublet regimens; thus, their framework can be used for
quantitative estimation of the in vivo cell-killing ability of various avenues of chemotherapy. …

[HTML][HTML] MicroRNA expression profiling and biomarker validation in treatment-naïve and drug resistant non-small cell lung cancer

L MacDonagh, MF Gallagher, B Ffrench… - … lung cancer research, 2021 - ncbi.nlm.nih.gov
… checkpoints, cisplatin-doublet chemotherapy remains the … micro-dissection/determination
of cancer cell percentages from … predicting response to cisplatin-based chemotherapy and the …

[HTML][HTML] … in personalized in silico oncology: coupling cell kinetics with metabolism, signaling networks, and biomechanics as plug-in component models of a cancer …

E Kolokotroni, D Abler, A Ghosh, E Tzamali… - Journal of personalized …, 2024 - mdpi.com
… The core algorithms of the Lung and WT Oncosimulators have been previously developed
by the In Silico Oncology and In Silico Medicine Group, and the implementation details can be …

Toward personalized computer simulation of breast cancer treatment: A multiscale pharmacokinetic and pharmacodynamic model informed by multitype patient data

X Lai, OM Geier, T Fleischer, Ø Garred, E Borgen… - Cancer research, 2019 - AACR
… We plotted the time evolution of the cancer cell density, defined as the proportion of grid …
In silico oncology: quantification of the in vivo antitumor efficacy of cisplatin-based doublet