… biography of single individuals from an evolutionary perspective. … inflammaging determined
by the accumulation of senescent cells. These active metabolic cells produce immune-…

… 2000 entitled “Inflammaging: an evolutionary perspective on … , signaling pathway, and
metabolic changes with aging … the occurrence of so-called age-related diseases (ARD) which are …

… immune cell–mediated inflammaging and its centrality between frailty syndrome and age-related
diseases… simplex virus-1, or by metabolic products or cellular debris from damaged or …

… in tissues and promote inflammaging. Age-related increases in endoplasmic reticulum stress
… such as TNF, IL-1, and IL-6 upon stimulation with immune complexes and TLR ligands [ …

… Mechanistically, both epigenetic and metabolic changes … if we put inflammaging in an
evolutionary perspective [16]. … , taking advantage of these age-related changes, which is how ARD …

… of chronic inflammatory disorders, cancer, and many age-related diseases. … standpoint, the
features of altered metabolic demands related to cellular senescence and inflammaging that …

… “inflammaging.” This is believed to substantially contribute to the pathogenesis of many
age-related diseases … Indeed, dysbiosis plays a role in sub-optimal metabolism, immune function …

… Age-related changes in the immune and metabolic responses are also recognized as playing
a critical pathogenic role in most common chronic medical conditions … fresh perspective in …

… termed “inflammaging”. This review will focus on age-related changes in the immune system
… , it is important to consider the metabolic and mitochondrial functions that are also altered …

… Although the inflammaging theory has served well in … it into metabolic and age-related
inflammatory responses. … , provide diverse views on changes in age-related chronic inflammation …