Intranasal cerium oxide nanoparticles ameliorate cognitive function in rats with Alzheimer's via anti-oxidative pathway
Cerium oxide nanoparticles (CNPs), owing to their antioxidant property, have recently
emerged as therapeutic candidate for Alzheimer's disease (AD). However, intravenous
CNPs are limited due to their poor physicochemical properties, rapid blood clearance and
poor blood–brain penetration. Thus, we developed intranasal CNPs and evaluated its
potential in experimental AD. CNPs were synthesized using homogenous precipitation
method and optimized through Box–Behnken Design. The formation of CNPs was confirmed …
emerged as therapeutic candidate for Alzheimer's disease (AD). However, intravenous
CNPs are limited due to their poor physicochemical properties, rapid blood clearance and
poor blood–brain penetration. Thus, we developed intranasal CNPs and evaluated its
potential in experimental AD. CNPs were synthesized using homogenous precipitation
method and optimized through Box–Behnken Design. The formation of CNPs was confirmed …
[PDF][PDF] Intranasal cerium oxide nanoparticles ameliorate cognitive function in rats with alzheimer's via anti-oxidative pathway. Pharm. 2022; 14 (4): 756
Cerium oxide nanoparticles (CNPs), owing to their antioxidant property, have recently
emerged as therapeutic candidate for Alzheimer's disease (AD). However, intravenous
CNPs are limited due to their poor physicochemical properties, rapid blood clearance and
poor blood–brain penetration. Thus, we developed intranasal CNPs and evaluated its
potential in experimental AD. CNPs were synthesized using homogenous precipitation
method and optimized through Box–Behnken Design. The formation of CNPs was confirmed …
emerged as therapeutic candidate for Alzheimer's disease (AD). However, intravenous
CNPs are limited due to their poor physicochemical properties, rapid blood clearance and
poor blood–brain penetration. Thus, we developed intranasal CNPs and evaluated its
potential in experimental AD. CNPs were synthesized using homogenous precipitation
method and optimized through Box–Behnken Design. The formation of CNPs was confirmed …
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