This paper presents and evaluates a simple but effective approach for substantially reducing inter-frequency handover (HO) failure rate. We build a machine learning model to forecast inter-frequency HO failures. For improved accuracy compared to the state-of-the-art models, we use domain knowledge to identify and leverage the model input features. These features include reference signal received power (RSRP) of the source and target base stations as well as the RSRP of the interferers for both the source and the target layers. Six machine learning classifiers are tested with the highest accuracy of 93% observed for the XGBoost classifier. The novel idea to include the RSRP of the interferes improved the accuracy of XGBoost by 10%.