An emerging, rapidly spreading coronavirus SARS-CoV-2 is causing a devastating
pandemic. As we have not developed curative medicine and effective vaccine, the end of
this life-threatening infectious disease is still unclear. Severe COVID-19 is often associated
with hypercytokinemia, which is typically found in macrophage activation syndrome. SARS-
CoV-2 infection causes this strong inflammation within the lung and propagates to
respiratory and, ultimately, systemic organ malfunction. Although we have not fully …

The current coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has the worst affected the entire
population on the earth (1, 2). This is currently a major concern for the global health care
system, as declared by the World Health Organization (WHO). Ample pieces of evidences
suggested the idiopathic association of the SARS-CoV-2 with many diseases in COVID-19
cases. Given the aberrant immunopathology of COVID-19, a single approach may not be …