… detail, perturbations in cholesterol homeostasis on a cellular … behaviors that may contribute
to plaque development. Thus, … miR-33 and miR-27b may also indirectly regulate cholesterol …

… –knockout mice are predisposed to the development of obesity and metabolic dysfunction,
we sought to determine the extent to which hepatic miR-33 contributes to this phenotype. …

… A key protein involved in this disorder is the transmembrane protein ABCA1, which is
responsible for cholesterol homeostasis and plasma membrane remodelling. This transporter …

… target of miR-33 responsible for its ability to regulate macrophage cholesterol efflux and …
Although miR-33 like many microRNAs can mediate complex physiological effects in vivo, …

… regulatory system against the influence of TAC on miR-33. Because noncoding RNAs, such
as circular RNAs (circRNAs) regulate … regulation of miR-33 function and feedback regulation. …

… the impact of miR-33 on cholesterol homeostasis, and … miR-33 is one of the essential
regulatory elements necessary to maintain a balance between dietary and blood cholesterol. This is …

… of miR‐33 within different tissues and begin to define the specific mechanisms by which
miR‐33 contributes to … This review will summarize what is known about miR‐33 and highlight …

… with disrupted cholesterol homeostasis and … cholesterol efflux, and high serum HDL cholesterol
compared to WT mice [100]. In-vivo overexpression of miR-33 via lentiviral delivery leads …

… that miR‐33 potentially affects many biological pathways, including cholesterol homeostasis.
In vivo deletion or inhibition of miR‐33 using antisense oligonucleotide improved the serum …

… Next, to understand how miR-33 silencing altered the expression of miR-33 target … –miR-33
and control anti-miR–treated mice obtained by scRNA-seq with the list of predicted miR-33 …