Anti-miR33 therapy improved hepatopancreatic lipid and immune metabolism disorders in grass carp, Ctenopharyngodon idella

RH Lu, MJ Lin, F Yang, S Jia, YR Zhang, CB Qin… - Fish Physiology and …, 2021 - Springer
… Several investigations have localized miR-33 in the … regulation and maintains cholesterol
homeostasis (Najafi-Shoushtari et al., 2010; Horie et al., 2010). This study found that miR-33

[HTML][HTML] MicroRNA-206 as a Potential Cholesterol-lowering Drug is Superior to Statins in Mice

C Li, J Tian, N Liu, D Song, CJ Steer, Q Han… - Journal of Lipid …, 2024 - Elsevier
… Taking into account the impact of the HFHC diet on cholesterol synthesis, our subsequent
investigation sought to compare how miR-206 and statins influence cholesterol homeostasis

Regulation of cholesterol homeostasis in osteoporosis mechanisms and therapeutics

C Bao, T Wu, S Zhu, X Wang, Y Zhang, X Wang… - Clinical …, 2023 - portlandpress.com
… of cholesterol homeostasis and its relationship with osteoporosis (including cholesterol and
cholesterol … A study recently identified that miR-33, miR-122, and miR-370 play key roles in …

Portulaca oleracea L. Extract Regulates Hepatic Cholesterol Metabolism via the AMPK/MicroRNA-33/34a Pathway in Rats Fed a High-Cholesterol Diet

S Jang, MS Lee, SA Kang, CT Kim, Y Kim - Nutrients, 2022 - mdpi.com
… the early stages of atherosclerosis can restore cholesterol homeostasis [12]. … miR-33 and
miR-34a levels [47,48]. In this study, we found for the first time that PE regulates hepatic miR-33

Uncovering the Specific Functions of miR-33 in Regulation of Feeding and Cardiometabolic Diseases Linked to Aging

N Price, X Zhang, P Fernandez-Tussy… - Innovation in …, 2020 - academic.oup.com
… of miR-33 may be responsible. To address these questions, we have generated conditional
miR-33 knockout mice to selectively remove miR-33 … of how miR-33 impacts the function of …

miR-32-5p induces hepatic steatosis and hyperlipidemia by triggering de novo lipogenesis

YD Wang, LL Wu, YN Mai, K Wang, Y Tang, QY Wang… - Metabolism, 2023 - Elsevier
… to regulate hepatic lipid metabolism [4,9,10]. In particular, miR-122 and miR-33 have been
… -2 predominantly regulates genes controlling cholesterol homeostasis, such as HMGCR and …

Cholesterol homeostasis: Researching a dialogue between the brain and peripheral tissues

M Gliozzi, V Musolino, F Bosco, M Scicchitano… - Pharmacological …, 2021 - Elsevier
… The aim of this review is to clarify the role of cholesterol homeostasis in health and disease
highlighting new intriguing aspects of the cross talk between its central and peripheral …

microRNA-33 controls hunger signaling in hypothalamic AgRP neurons

NL Price, P Fernández-Tussy, L Varela… - Nature …, 2024 - nature.com
… that miR-33 plays a critical role in the regulation of AgRP neurons, and that loss of miR-33
leads to … These effects include the regulation of multiple miR-33 target genes involved in …

MicroRNA-33b is a potential non-invasive biomarker for response to atorvastatin treatment in chilean subjects with hypercholesterolemia: a pilot study

CG Ubilla, Y Prado, J Angulo, I Obreque… - Frontiers in …, 2021 - frontiersin.org
… (HMGCR) and sterol regulatory element-binding protein 2 (SREBF2). Therefore, miRNA-24
assists in regulating cholesterol homeostasis and steroidogenesis by repressing HDL uptake …

Effect of statins on lipid metabolism-related microRNA expression in HepG2 cells

A Cerda, RH Bortolin, V Manriquez, L Salazar… - Pharmacological …, 2021 - Springer
… Statin-induced HMGCR inhibition represses miR-33a/SREBF2, which in turn induces
HMGCR transcription to maintain cholesterol homeostasis [28]. Therefore, the upregulation of …