What's the target: understanding two decades of in silico microRNA-target prediction

F Kern, C Backes, P Hirsch, T Fehlmann… - Briefings in …, 2020 - academic.oup.com
… , miRNAs hybridize almost perfectly to their target site along the entire mature sequence, …
In turn, this property not only simplifies the search for target sites but also suggests a higher …

miRNA targets: from prediction tools to experimental validation

G Riolo, S Cantara, C Marzocchi, C Ricci - Methods and protocols, 2020 - mdpi.com
… This review summarizes the key strategies for miRNA target identification. Several tools
for … of the potential miR-622 targets in breast cancer, using an integrated miRNA prediction …

MicroRNA-small molecule association identification: from experimental results to computational models

X Chen, NN Guan, YZ Sun, JQ Li… - Briefings in bioinformatics, 2020 - academic.oup.com
… opportunity of miRNA target identification. Similarly, miRNA complementary sequences are
… ChemiRs is a web server that integrated various miRNA prediction methods and biological …

The biochemical basis of microRNA targeting efficacy

SE McGeary, KS Lin, CY Shi, TM Pham, N Bisaria… - Science, 2019 - science.org
… basis for quantitatively integrating miRNAs into gene-regulatory networks. … the bound library
sequences identified miRNA target sites, and relative K d values for each of these sites were …

miRDB: an online database for prediction of functional microRNA targets

Y Chen, X Wang - Nucleic acids research, 2020 - academic.oup.com
… In this way, we were able to identify features that are associated with miRNA target binding.
… improvements to the target prediction algorithm as well as integrate more heterogeneous …

miRBase: from microRNA sequences to function

A Kozomara, M Birgaoanu… - Nucleic acids …, 2019 - academic.oup.com
sequences from the database. To improve the availability of microRNA functional information,
we are disseminating Gene Ontology terms annotated against miRBase sequences. We …

Trends in the development of miRNA bioinformatics tools

L Chen, L Heikkinen, C Wang, Y Yang… - Briefings in …, 2019 - academic.oup.com
… starBase integrates several data sets about miRNA … for identification of miRNAs and isomiRs
using NGS data. Single-nucleotide polymorphism (SNP) on miRNA or on miRNA target site

Integration of bioinformatic predictions and experimental data to identify circRNA-miRNA associations

M Dori, S Bicciato - Genes, 2019 - mdpi.com
… These are obtained either using miRNA target prediction … , or combining Ago binding sites
with miRNA target predictions (… not excluding all the sites identified by single programs that still …

MicroRNAs and complex diseases: from experimental results to computational models

X Chen, D Xie, Q Zhao, ZH You - Briefings in bioinformatics, 2019 - academic.oup.com
identified miRNA target sites. It also includes a list of somatic mutations in the … a diffusion
algorithm and constructs the integrated adjacent matrixes for miRNAs and diseases, SD and SM…

MicroRNA detection specificity: recent advances and future perspective

T Ouyang, Z Liu, Z Han, Q Ge - Analytical chemistry, 2019 - ACS Publications
MicroRNAs (miRNAs) are a series of promising molecules that could regulate gene … , targeted
therapy, and prognosis of diseases. Improved detection accuracy of miRNAs would lead to …