Estimating residence times of lymphocytes in ovine lymph nodes

MM McDaniel, VV Ganusov - Frontiers in immunology, 2019 - frontiersin.org
models based on fundamental principles of lymphocyte … that pathogen-specific cell will
encounter its antigen (10, 11). … mature lymphocytes by acceleration of lymphocyte homing in …

Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance

R Martens, M Permanyer, K Werth, K Yu… - Nature …, 2020 - nature.com
… Little is known regarding lymph node (LN)-homing of immune … of LN homing of afferent
lymph-derived lymphocytes (… floor endothelium until they encounter preformed entry ramps that …

New tools for immunologists: models of lymph node function from cells to tissues

T Ozulumba, AN Montalbine… - Frontiers in …, 2023 - frontiersin.org
… to facilitate encounters between APCs and rare antigen-specific lymphocytes, thus … , (ii)
distribution of major stromal cell subsets; (iii) homing of naïve T cells into the node via high …

[HTML][HTML] Integrative lymph node-mimicking models created with biomaterials and computational tools to study the immune system

Y Shou, SC Johnson, YJ Quek, X Li, A Tay - Materials Today Bio, 2022 - Elsevier
… of the lymphatic vessel network and the lymph node architecture with specific lymphocytes.
A) … Here they may encounter their cognate antigen presented by antigen-bearing migratory …

An Integrated Spatial Dynamics—Pharmacokinetic Model Explaining Poor Penetration of Anti-retroviral Drugs in Lymph Nodes

A Jagarapu, MJ Piovoso, R Zurakowski - Frontiers in bioengineering …, 2020 - frontiersin.org
… exploring the inflamed lymph node. Those lymphocytes that do not encounter cognate antigen
… Several different groups have introduced lymph node models, all focusing on lymphocyte

Chemokines and other mediators in the development and functional organization of lymph nodes

N Eckert, M Permanyer, K Yu, K Werth… - Immunological …, 2019 - Wiley Online Library
… to include recent findings into existing models. Our focus is on … Without antigen encounter,
they egress through the cortical … lymphocyte homing via HEVs (Figure 2A). CXCR4-mediated …

Remodeling of reactive lymph nodes: Dynamics of stromal cells and underlying chemokine signaling

GR Thierry, R Gentek, M Bajenoff - Immunological Reviews, 2019 - Wiley Online Library
… LNs controls homeostatic lymphocyte homing and facilitates … the probability of lymphocytes
to encounter their antigen. At … The generation of such models will be instrumental to further …

L-selectin-dependent and-independent homing of naïve lymphocytes through the lung draining lymph node support T cell response to pulmonary Mycobacterium …

L Daniel, C Counoupas, ND Bhattacharyya… - PLoS …, 2023 - journals.plos.org
… Defects in these processes observed in tumour models and … naïve lymphocytes to lung-draining
mediastinal lymph node … of the lymph node is to increase the probability of encounter

Modelling the effects of lymph node swelling on T-cell response

SC Johnson, J Frattolin, LT Edgar, M Jafarnejad… - bioRxiv, 2020 - biorxiv.org
… The lymphatic system is a network of organs and lymphatic … delivers crucial antigen information
to lymph nodes (LNs) for … blood to lymph nodes and its relation to lymphocyte traffic and …

Lymph Node-on-Chip Technology: Cutting-Edge Advances in Immune Microenvironment Simulation

Q Wang, Y Yang, Z Chen, B Li, Y Niu, X Li - Pharmaceutics, 2024 - mdpi.com
… the homing and localization of DC in the lymphatic system [52,… However, large molecules
encounter more resistance during … function is the unique spatial categorization of lymphocytes, …