… and reduce IFN-1 production by inducing the proteasomal … hand, NLRX1 inhibits IRF3
dimerization mediated by MAVS; … with dsRNA to promote virus-induced upregulation of IRF1 …

… in the innate immunity of teleost fish, NLRX1 homologue has … restrained RLR/MAVS/IFN
signaling by attenuating the antiviral … of NLRX1-HA, which implied that this protein was degraded …

… that NLRX1 attenuated the innate immune response through interacting with MAVS and …
cancer immune evasion via NLRX1-mediated degradation of STING [65]. Taken together, …

… MAVS is complex, as other molecules like PSMA7, FAF1, STING, PB1-F2, and PKR might
function concurrently with NLRX1 to impact innate immunity… rhinovirus-mediated disruptions to …

… MAVS modulates MAVS ubiquitination-mediated degradation. … production, attenuation of
lactate-mediated MAVS inhibition, … the proteasomal degradation of MAVS via GP73 or NLRX1. …

… NLRX1 negatively regulates Sendai virus-induced type I IFN production by inhibiting MAVS
mediated IRF3 … that NLRX1 mostly controls the RLR-mediated innate immune responses of …

… In the field of innate immunity, NLRX1 has still gained a lot of … that NLRX1 induced the
degradation of MAVS through … but not in primary cells, NLRX1 mediated resistance to …

… MAVS mediated innate immune activation. For example, … like NLRX1 and DUBs regulate
RIG-I binding to MAVS at the … outbreaks and rapid spread of RNA-virus induced infection. …

… and inhibit NF-κB-mediated proinflammatory cytokine production by targeting the TAK1 …
NLRX1 is also reported to attenuate IAV induced inflammation by meddling with the RIG-I-MAVS …

… degradation of MAVS, further inhibiting RIG-I/MAVS signalling … suggest that NLRX1 may
regulate innate immunity through … To understand the mechanism of NLRX1-mediated mitophagy…