… The endonuclease resides within the N-terminal domain of the PA subunit (PA N ) of the
influenza RNA dependent RNA … The complex structures reveal that the single nucleotide …

… monophosphate and acts on cellular enzyme inosine 5′-… and induce conformational
changes of PA endonuclease. … and linker domains and prevent the activity of influenza RdRp …

… inhibitor targeting the influenza virus polymerase PA N-terminal endonuclease domain (PA …
This work describes the first crystal structures of BXA in complex with E23K and A36V PA N …

… Domain 2 is composed of β8 and β9 and α4, α5 and α8–α12, … bonds on the nucleotide
substrate and excise the nucleotide chain. … Researchers used viral ribonucleoprotein complexes …

… layer is the approximately 13,500 nucleotide (nt) viral genome, … , allowing for the endonuclease
domain to cleave capped … of importin α, thus recruiting importin β to the complex [159]. …

… endonuclease-polymerase replication complexes, with cryo-EM and X-ray crystallographic
structures recently resolved for the polymerases of influenza … residues for nucleotide addition …

… Influenza A virus proteins and life cycle ...................................................... 3 1.1.3. Infection and
… Modulation of host gene expression by influenza A virus .................................... 9 1.2.1. Normal …

… influenza virus polymerases, the Endo domain and domains … that leads to formation of a
monophosphate RNA–L protein … to the structural similarity of endonucleases among sNSV …

… endonuclease (forest green), PA-C-terminal domain (green), PB1 (cyan), PB2-N (red),
PB2-midlink domain (magenta), PB2-cap-binding domain (… -EM structure of this product complex, …

… form of the FDA approved influenza endonuclease (PA) inhibitor … can excise incorporated
nucleotide analogues with … cap binding domain of PB2 between different genera of influenza (…