… 15 nucleotide upstream by PA (ie, the acidic subunit of RdRp) … The 5′-monophosphate
mRNA is transferred to the GDP … were performed for influenza virus endonuclease domain (PA-…

… , which has the functions of nucleotide polymerization and … structure of 2009 H1N1 influenza
A endonuclease domain (PA … inhibitor of host monophosphate dehydrogenase (IMPDH) and …

… propensity to form complex secondary and tertiary structures [6… CNBP was shown to become
phosphorylated upon influenza … viral RNA via its NYN endonuclease domain [147]. ZAP can …

… We present crystal structures of the catalytic domain of … may accommodate a 4-nucleotide
loop connecting the two paired … with two deoxyadenosine monophosphate nucleotides and …

… -binding domain 9 , cleaved by the PA endonuclease domain 8 , … first nucleotide of the
3′-vRNA template or at nucleotide 4 … no structures published for an equivalent Flu A Pol complex, …

… nucleotide analogues 35a,b, 36a,b with the monophosphate … of the protein PA-Nter
endonuclease domain (PDB code 4AWK)… We used the structure of the hemagglutinin H1 of …

… public health crisis since the Spanish Flu of 1918. Combination … including inosine
monophosphate dehydrogenase inhibition … such endonuclease inhibitors with nucleoside analogs …

… ; residues 1–197) and C-terminal fragments of PA (PA C , ≈55 kDa C-terminal domain;
residues 239–716) are two domains of PA. The crystal structure of PA C is solved in complexes …

… a complex molecule that consists of various nucleotide regions… to release the monophosphate
and RNA diphosphate (pp-RNA… The PA endonuclease of influenza virus also preferentially …

… During influenza virus infection, PA-C of the RNP complexes … domain and PA N-terminal
endonuclease. The cap-binding … a G nucleotide at 3’ end can also pair up with C nucleotide at …