… the active site of the influenza endonuclease is located in the … of the nucleoside analogue
to its 5’-monophosphate form. … terminal domain of the RdRp acidic subunit of influenza virus …

… search for influenza antivirals among nucleoside analogues … analogue and its structure is
the closest to the structure of the … PA containing the N-terminal endonuclease domain (PA-Nter) …

… of nucleoside transporters and afford a monophosphate form of … the synthesis and antiviral
evaluation against influenza A (H1N1) … We chose the N-terminal endonuclease domain of the …

… domain (PB2-Cap) and PA-N-terminal endonuclease … Its anti-influenza effect is based on
inosine monophosphate (IMP… depletion and an imbalance in the nucleotide pools. In particular, …

… containing the N-terminal endonuclease domain (PA-Nter) of … of a nucleoside analogue
to its 5-monophosphate form. … ) influenza virus and cytotoxicity of 1,2,3-triazolyl nucleoside …

… The 2′-O-methyl groups of the first and second nucleosides are highlighted in turquoise …
subunits of the flu RNA polymerase complex (which also includes the PA endonuclease). This …

… to the 5′-monophosphate viral mRNA, and … influenza C virus) with endonuclease activity
carries out a precise cleavage of the nucleotide situated downstream of the host cap structure. …

… have another nucleotide incorporated (yet majority still being adenosine monophosphate) …
domain structures. Thin lines – Klenow fragment, thick lines – Taq polymerase; C) Differing …

… Exo1 and Exoλ), while endonucleases are able to incise inside … the nucleotide monophosphate
product from the catalytic site. … Catalytic domain of hExo1 in complex with DNA substrate …

… the active site of the target endonuclease domain of the RNA-… published structures of
endonuclease-substrate complexes, … interacts with the nucleotide in the RNA complex. A potential …