… in the binding site of the influenza RNA polymerase PA N endonuclease. We modeled the
… RNA polymerase complex. This highly conserved domain regulates the lifecycle of the virus, …

… drugs include nucleotide analogue of cytosine monophosphate, … to the endonuclease domain
(pUL89-C) remain unknown. … series of potent influenza virus PA endonuclease inhibitors …

… with a uridine monophosphate, suggesting initiation via a … , this domain is similar to the
endonucleases of the influenza … a helical RNP-like structure with tri-nucleotide RNAs (orange) …

… universally use nucleotide binding oligomerization domain–… Selected structures of activated
complexes are shown as … N-terminal effector domains, including DNA endonucleases, to …

… activated oxygen that breaks a nucleotide linking OP bond. The … structure of the N-terminal
domain of the PA endonuclease (… crystal structure of Influenza A PA N endonuclease bound to …

… PB2 forms the viral RNA polymerase complex [39]. The endonuclease activity of PA is
responsible … antiviral activity, including influenza, was found for the nucleosides formycin A and B …

… realignment results in an extra G nucleotide at the 5′ end of the … the structure of the
heterotrimeric influenza virus polymerase … However, in this structure, we see the endonuclease in …

… -dependent PA N endonuclease domain of the enzyme, is an … not only block the influenza
PA N endonuclease but also the … formation of the nucleotide monophosphate product and the …

… endonuclease domain of the polymerase, highly conserved among various historic influenza
… is trapped by the PB2 domain and cleaved at the 8–14 nucleotide to serve as a primer for …

… C-adenosine monophosphate prodrug derived from the parent nucleoside GS-441524 (Fig. …
the trimeric influenza replication complex, possessing an N-terminus endonuclease, RdRp …