… in the increased transcription of genes regulating oncogenic signaling pathways [68]. …
PI3K/Akt pathway, and dysregulation of the mediators of the insulin signaling pathway is observed …

… In addition, we highlight recent findings pointing to the role of the dysregulated activity of
BCL-2 proteins and protein tyrosine phosphatases (PTPs) in the generation of …

… Nonalcoholic fatty liver disease affects about 24% of the world’s population and may
progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). …

… signaling pathways, and transforming these into oncogenic … that obesity-associated
metabolic signaling pathways can … Therefore, the slight dysregulation of the Hippo pathway …

… with the development of hepatocellular carcinoma (HCC) pose … Finally, obesity-associated
changes in the gut microbiota … of the TME, while it exerts oncogenic effects in HepG2/C3C cell …

… HCC may suggest the dysregulation of metabolic processes, … role in the development of
obesity-associated HCC. Dietary or … The patterns of genomic alterations and potential oncogenic …

… pathways that may contribute to HCC development. In obesity-linked HCC, oncogene-induced
modifications and metabolic pathways … utilization of signaling pathways and metabolic …

… of several rare mutations may be required to activate oncogenes, or inactivate … pathway, in
obese mice with HCC [15]. Characterizing the obesity-associated mutations in cancer patients …

… serum markers of obesity-associated hepatocellular carcinoma (HCC… and mutations in
proto-oncogenes and tumor suppressor genes, … In turn, the dysregulated PI3K/Akt pathway further …

… overweight/obesity-associated transcriptome was identified … The dysregulation of fatty acid
metabolism might directly result … on-oncogene alterations are engendered, compared to the …