… Female Swiss mice were administered by oral gavage for 5 consecutive days. Two silica …
Although we attempted to evaluate S100A8/A9 levels, the matrix affected the robustness of …

… Oropharyngeal administration of silica in Swiss mice: A robust and reproducible model of
occupational pulmonary fibrosis. Pulm Pharmacol Ther 51, 32–40, https://doi.org/10.1016/j.pupt…

… Mice were experimentally infected with Schistosoma mansoni and treated 6 weeks post-…
after oral administration. It was reported that NPs, due to their small particle size, enable strong …

… injury and results in more robust fibrosis present in the lungs 57. … An animal model needs to
be reproducible and uniform, … optimized a silica-induced pulmonary fibrosis mouse model on …

… intravenous administration (IV) to mice for up to 8 weeks of silica … that oral gavage of 25 nm
nanostructured silica to rats … (∼600 nm diameter) caused strong local membrane deformation …

… In addition to the size, the same work also points to strong … in ICR mice, there were observable
amount of silicon in liver, … For technology transfer, it is paramount to have a reproducible …

… reliable and comparable results based on the principle of “stable stool,” in this case with four
legs: (i) validation, (ii) traceability, (iii) quality-management … silica particles in rats and mice …

… Acute exposure to Aroclor 1232 showed reproducibility of … ) or the gastrointestinal tract (oral
exposures). But an especially … of research data to humans more reliable in the latter. …

… On this basis, this study established mouse models of pulmonary fibrosis closer to human …
administration Thirty-five healthy mice were randomly divided into five groups with seven mice …

… [51] also observed a strong pH dependence of methotrexate … Oral and ocular administration
of nonporous silica … human, reproducibility, stability and scalability of the silica nanoparticles …