PPARs-orchestrated metabolic homeostasis in the adipose tissue

C Sun, S Mao, S Chen, W Zhang, C Liu - International journal of …, 2021 - mdpi.com
… mice, adipose tissue-specific loss of PPARγ led to critical atrophy of adipose tissue and
was … mutants in human subjects also supports the important role of PPARγ in adipose tissue

Increase in leptin and PPAR-γ gene expression in lipedema adipocytes differentiated in vitro from adipose-derived stem cells

S Al-Ghadban, ZT Diaz, HJ Singer, KB Mert… - Cells, 2020 - mdpi.com
… Our team and others have shown that lipedema adipose tissue is a highly vascularized and
fibrotic tissue with an increase in blood vessels, infiltrating macrophages and hypertrophic …

In vitro and ex vivo models of adipocytes

J Dufau, JX Shen, M Couchet… - … of Physiology-Cell …, 2021 - journals.physiology.org
… It may take place during adulthood, allowing adipocyte turnover and adipose tissue
Whereas the requirement of PPARγ agonists is mandatory for optimal differentiation of human …

[HTML][HTML] PPARγ and PPARα synergize to induce robust browning of white fat in vivo

T Kroon, M Harms, S Maurer, L Bonnet… - Molecular …, 2020 - Elsevier
… and subsequent synergistic effect with PPARγ activation in adipose tissues. Indeed, tesaglitazar
… correlated with Ucp1 levels in adipose tissues in all in vivo studies performed with dual …

Feedback regulation of Arid5a and Ppar-γ2 maintains adipose tissue homeostasis

JP Chalise, S Hashimoto, G Parajuli… - Proceedings of the …, 2019 - National Acad Sciences
… , a process of forming adipocytes from fibroblast cells. In this … Further, we showed adipose
tissue homeostasis is maintained … into the novel mechanism of adipose tissue homeostasis. …

The importance of the nuclear positioning of the PPARG gene for its expression during porcine in vitro adipogenesis

J Stachecka, J Nowacka-Woszuk, PA Kolodziejski… - Chromosome …, 2019 - Springer
… Given the importance of PPARγ in the development of adipose tissue, understanding the
molecular mechanisms that regulate its expression is highly important in the context of human …

GADD45α drives brown adipose tissue formation through upregulating PPARγ in mice

W You, Z Xu, Y Sun, TG Valencak, Y Wang… - Cell death & …, 2020 - nature.com
vivo and in vitro data suggest that GADD45α deficiency may promote proliferation and
lipolysis in brown adipocytes… brown adipocytes differentiation via interacting with PPARγ to …

The Role of Dietary Phytoestrogens and the Nuclear Receptor in Adipogenesis: An in Vitro Study

JM Hall, HR Powell, L Rajic… - Environmental health …, 2019 - ehp.niehs.nih.gov
… PCR of PPARγ target genes in 3T3L1 pre-adipocytes and differentiated adipocytes in the …
phytoestrogens may be also activating ERs in adipose tissue. Unlike PPAR γ , activated ERs …

Macrophages inhibit adipogenic differentiation of adipose tissue derived mesenchymal stem/stromal cells by producing pro-inflammatory cytokines

H Ma, Y Li, L Song, R Liu, X Li, Q Shang, Y Wang… - Cell & bioscience, 2020 - Springer
adipocyte differentiation of hADSC in vitro, whether the findings can be translated to the
physiological and pathological conditions in vivo … interact with ADSCs in vivo also needs to be …

HSPA12A is required for adipocyte differentiation and diet-induced obesity through a positive feedback regulation with PPARγ

X Zhang, X Chen, T Qi, Q Kong, H Cheng… - … Death & Differentiation, 2019 - nature.com
… by excessive accumulation of white adipose tissue (WAT), … required for adipocyte differentiation
via maintaining PPARγ expression. Inversely, we also identified the regulation of PPARγ