[HTML][HTML] The PRC2 complex epigenetically silences GATA4 to suppress cellular senescence and promote the progression of breast cancer
W Yu, X Lin, S Leng, Y Hou, Z Dang, S Xue, N Li… - Translational …, 2024 - Elsevier
… of EZH2 on GATA4 transcriptional activity, we overexpressed … PRC2 interacts with GATA4
and regulates lysine methylation… transcriptional repression of FAS by PRC2, partly through the …
and regulates lysine methylation… transcriptional repression of FAS by PRC2, partly through the …
GATA factor transcriptional activity: Insights from genome‐wide binding profiles
… at some repressed genes in erythroid and megakaryocytic cells, which suggests that PRC2
is involved in … Endothelial genes normally repressed by GATA4 are upregulated in mutated …
is involved in … Endothelial genes normally repressed by GATA4 are upregulated in mutated …
PRC2. 1 and PRC2. 2 synergize to coordinate H3K27 trimethylation
… This supports a model in which the specific accessory proteins within PRC2.1 and PRC2.2
cooperate to direct H3K27me3 via both synergistic and independent mechanisms. …
cooperate to direct H3K27me3 via both synergistic and independent mechanisms. …
A dimeric structural scaffold for PRC2-PCL targeting to CpG island chromatin
… for lysine methylation and serve as the catalytic subunit of PRC2. … PRC2 core complex,
which reciprocally enhances the binding of PCLs to CGI DNAs in pairs for gene repression…
which reciprocally enhances the binding of PCLs to CGI DNAs in pairs for gene repression…
GATA4 regulates mesenchymal stem cells via direct transcriptional regulation of the WNT signalosome
… in Gata4 Prx-cKO mice. We suggest that WNT signalosome activity in MSCs requires Gata4
and … We have also shown that GATA4 represses RANKL gene expression in osteoblasts. …
and … We have also shown that GATA4 represses RANKL gene expression in osteoblasts. …
Going beyond Polycomb: EZH2 functions in prostate cancer
… by DNA methylation and transcriptional activity. Accordingly, inhibition of transcription induced
global recruitment of PRC2 to … A PRC2 methylates and represses GATA4 activity, whereas …
global recruitment of PRC2 to … A PRC2 methylates and represses GATA4 activity, whereas …
The DNA dioxygenase Tet1 regulates H3K27 modification and embryonic stem cell biology independent of its catalytic activity
… , thereby facilitating gene repression in ESCs (21,23). This is … We show that Tet1 facilitates
recruitment of PRC2 (for H3K27 … loss of its catalytic activity increases global DNA methylation, …
recruitment of PRC2 (for H3K27 … loss of its catalytic activity increases global DNA methylation, …
BACH1 recruits NANOG and histone H3 lysine 4 methyltransferase MLL/SET1 complexes to regulate enhancer–promoter activity and maintains pluripotency
C Niu, S Wang, J Guo, X Wei, M Jia… - Nucleic Acids …, 2021 - academic.oup.com
… These super-enhancers have high transcriptional activity and regulate essential pluripotent
… that BACH1 repressed the transcription of mesendodermal genes via recruiting PRC2 to …
… that BACH1 repressed the transcription of mesendodermal genes via recruiting PRC2 to …
Genetic and epigenetic control of heart development
BN Akerberg, WT Pu - Cold Spring Harbor perspectives …, 2020 - cshperspectives.cshlp.org
… interacts with FOG2, a direct modulator of GATA4 transcriptional activity. One target of …
identified PRC2 methylation of nonhistone targets as an additional mechanism of gene repression. …
identified PRC2 methylation of nonhistone targets as an additional mechanism of gene repression. …
PRC1 sustains the integrity of neural fate in the absence of PRC2 function
A Sawai, S Pfennig, M Bulajić, A Miller… - Elife, 2022 - elifesciences.org
… is thought to repress gene expression in a PRC2dependent … expressed Hox13 paralogs
directly repress multiple Hox genes … of histone methylation marks deposited by PRC2 activity. …
directly repress multiple Hox genes … of histone methylation marks deposited by PRC2 activity. …