Small vessel disease: mechanisms and clinical implications

JM Wardlaw, C Smith, M Dichgans - The Lancet Neurology, 2019 - thelancet.com
… Most small vessel disease is sporadic, perhaps related to hypertension or other vascular
risk factors, but a small proportion is due to rare genetic variants, of which the commonest is …

[HTML][HTML] Asymptomatic cerebral small vessel disease: insights from population-based studies

AS Das, RW Regenhardt, MW Vernooij, D Blacker… - Journal of …, 2019 - ncbi.nlm.nih.gov
… , hypertension was not associated with CMB, perhaps explained by the fact that this study
included fewer subjects with deep CMB (of which hypertension … whereas previous population-…

Inflammation and cerebral small vessel disease: a systematic review

A Low, E Mak, JB Rowe, HS Markus, JT O'Brien - Ageing research reviews, 2019 - Elsevier
… of vascular inflammation tended to be associated with SVD in areas typical of hypertensive
… increased dramatically in the last decade, bringing with it a new set of problems, such as the …

Association between blood pressure variability and cerebral smallvessel disease: a systematic review and meta‐analysis

PJ Tully, Y Yano, LJ Launer, K Kario… - Journal of the …, 2020 - Am Heart Assoc
previousantihypertensive drug versus placebo RCTs. By contrast, our review included
only included 1 RCT, which might explain why the use of antihypertensive drug or hypertension

[HTML][HTML] Clinical relevance of cerebral small vessel diseases

M Pasi, C Cordonnier - Stroke, 2020 - journals.lww.com
… The former describes a group of small vessel pathological processes. Arteriolosclerosis has
Hypertension and diabetes mellitus are said to be strongly associated with lacunar stroke. …

CNS small vessel disease: a clinical review

RJ Cannistraro, M Badi, BH Eidelman, DW Dickson… - Neurology, 2019 - AAN Enterprises
… that indicates the previous extravasation of blood from damaged small vessels (…
antihypertensive medication on CSVD showed that patients in the intensive antihypertensive

Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis

U Clancy, D Gilmartin, ACC Jochems, L Knox… - The Lancet …, 2021 - thelancet.com
… Cerebral small vessel disease, a common cause of vascular … However, some individuals
have subtle symptoms associated … symptoms vary according to small vessel disease burden. …

Cerebral small vessel disease: recent advances and future directions

HS Markus, FE de Leeuw - International Journal of Stroke, 2023 - journals.sagepub.com
… caused by aging, hypertension, and other conventional vascular risk factors, and cerebral
… This matches well with a previous systemic review based largely on data from high-income …

Global burden of small vessel diseaserelated brain changes on MRI predicts cognitive and functional decline

H Jokinen, J Koikkalainen, HM Laakso, S Melkas… - Stroke, 2020 - Am Heart Assoc
small vessel disease is characterized by a wide range of focal and global brain changes. We
used … quantify multiple types of small vessel diseaserelated brain changes and examined …

Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease

SM Wong, JFA Jansen, CE Zhang, EI Hoff, J Staals… - Neurology, 2019 - AAN Enterprises
… (A) of a 73-year-old woman with cerebral small vessel disease and maps with values for
cerebral … risk factors, for example hypertension, by using antihypertensive drugs 34 or smoking …