Hepatic inflammation confers protective immunity against liver stages of malaria parasite

M Grand, M Waqasi, C Demarta-Gatsi, Y Wei… - Frontiers in …, 2020 - frontiersin.org
… and immunity against liver stage Plasmodium infection. … −/− mice will result in adaptive
immune protection against … of Mdr2 −/− mice as a mouse model for malaria infection allowed us to …

Memory CD8+ T cell‐mediated protection against liverstage malaria

M Hassert, S Arumugam, JT Harty - Immunological reviews, 2023 - Wiley Online Library
… The use of various vaccination strategies in both mouseTargeting vaccines to the malaria
preerythrocytic stage is an … Not only would this new mouse model of DC-LM prime boost …

Cutting edge: subunit booster vaccination confers sterilizing immunity against liver-stage malaria in mice initially primed with a weight-normalized dose of radiation …

MN Lefebvre, LL Drewry, LL Pewe… - The Journal of …, 2021 - journals.aai.org
… We find that liver-stage malaria-specific memory CD8 T cells primed by weight-adjusted
RAS vaccination can be numerically … Prime and target immunization protects against liver-stage

Immune responses to malaria pre‐erythrocytic stages: implications for vaccine development

KM Abuga, W Jones‐Warner… - Parasite immunology, 2021 - Wiley Online Library
mice immunized with radiation-attenuated sporozoites (RAS) demonstrated sterile immune
protection against malaria … (CPS vaccines), which acts on blood stage but not liver-stage

Improving the immunogenicity and protective efficacy of a whole‐killed malaria blood‐stage vaccine by chloroquine

Y Fu, X Lu, F Zhu, Y Zhao, Y Ding, L Ye… - Parasite …, 2020 - Wiley Online Library
… designation and the high polymorphism of the target … CQ than in mice receiving sera from
mice immunized with WKV … developed from the liver stage, leaving the unaffected liver stage to …

Current challenges in the identification of pre-erythrocytic malaria vaccine candidate antigens

P Bettencourt - Frontiers in Immunology, 2020 - frontiersin.org
… done to identify liver-stage protective antigens from P. falciparum, … This study revealed that
sterile protection against malarialiver-stage response against malaria antigens using mouse

Accelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine

Z MacMillen, K Hatzakis, A Simpson, MJ Shears… - npj Vaccines, 2024 - nature.com
… to liver-stage parasites, leading to sterile protection. … To determine if prime-and-trap vaccination
can protect against a … to reconstitution, and secondly on direct targeting of the liver, in the …

Liver-Directed AAV8 Booster Vaccine Expressing Plasmodium falciparum Antigen Following Adenovirus Vaccine Priming Elicits Sterile Protection in a Murine Model

M Shahnaij, M Iyori, H Mizukami, M Kajino… - Frontiers in …, 2021 - frontiersin.org
… /c mice to evaluate the immune responses and protective … dissected from the mice that were
protected against sporozoite … parasite’s liver stage in preclinical settings. AAV8 is intensely …

Subcutaneous immunization with unaltered axenic malaria parasite liver stages induces sterile protection against infectious Sporozoite challenge

M Kamil, G Deveci, UY Kina, SHI Kappe, ASI Aly - Vaccines, 2022 - mdpi.com
… The transformation of sporozoites into early liver stage were … salivary gland sporozoites
challenge in immunized mice. Our … clinical trials using vaccines targeting clinically asymptomatic …

Ultra-low dose immunization and multi-component vaccination strategies enhance protection against malaria in mice

KA Collins, F Brod, R Snaith, M Ulaszewska… - Scientific Reports, 2021 - nature.com
… and vaccination strategies are being developed to target the … less immunogenic than the
normal prime boost regimen (AM… as sporozoite invasion or liver-stage development assay may …