Measuring biological aging in humans: A quest

L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
… drivers of biological aging. However, reliable and valid assays for their quantification
should be developed before they can be used in human research and in clinical applications. …

A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge

D Kwon, DW Belsky - Geroscience, 2021 - Springer
… Methods to quantify biological aging are emerging as new measurement tools for …
Publicly available software packages to compute biological aging measurements from DNA …

Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm

DW Belsky, A Caspi, L Arseneault, A Baccarelli… - Elife, 2020 - elifesciences.org
… a fourth, longitudinal, study of young people to test if DunedinPoAm was accelerated by …
slowed the rate of biological aging as measured by a blood-chemistry biological-age composite …

Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy

ML Elliott, A Caspi, RM Houts, A Ambler, JM Broadbent… - Nature aging, 2021 - nature.com
… , dental and pulmonary systems, and quantified age-related decline shared … biological
aging in the Dunedin Study the ‘Pace of Aging’. In a 2015 article, we quantified the Pace of Aging

Measuring biological age using omics data

J Rutledge, H Oh, T Wyss-Coray - Nature Reviews Genetics, 2022 - nature.com
… to quantify a composite rate of biological ageing 74 . The DunedinPoAm DNAm clock was
then trained with standard methods to estimate this rate with CpG methylation. This clock had …

Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort

ML Elliott, DW Belsky, AR Knodt, D Ireland… - Molecular …, 2021 - nature.com
… By quantifying each person’s personal pace of biological aging, we were able to
demonstrate that Study members with older brainAGE had experienced at least two decades of …

Biological age in healthy elderly predicts aging-related diseases including dementia

JW Wu, A Yaqub, Y Ma, W Koudstaal, A Hofman… - Scientific reports, 2021 - nature.com
… Using the more robust quantification of RNA-seq we determined expression levels of 2083
plasma miRNAs. Of these, 591 miRNAs remained as well-expressed after normalization. We …

Accelerating research on biological aging and mental health: Current challenges and future directions

LKM Han, JE Verhoeven, AR Tyrka… - …, 2019 - Elsevier
biological and non-biological factors. This article focuses on the link between biological aging,
… Currently, although we have some quantifiable measures of biological aging in humans - …

Biological aging in childhood and adolescence following experiences of threat and deprivation: A systematic review and meta-analysis.

NL Colich, ML Rosen, ES Williams… - Psychological …, 2020 - psycnet.apa.org
… with biological aging vary according to the nature of adversity experienced. ELA overall
was … CpG sites) to quantify biological age independent from chronological age (DNAm age) …

Sex differences in biological aging with a focus on human studies

S Hägg, J Jylhävä - Elife, 2021 - elifesciences.org
… studies, with support from animal research, on biological aging and illnesses. We also
attempt to place it in the context of the theories of aging, as well as discuss the explanations for …