… , highly mutagenic due to the challenges presented by the resulting … clustered DNA lesions
(OCDLs); throughout this review we will hereafter refer to the former as “clustered damage” …

… evidence that clustered DNA damage is more mutagenic and … has been on radiation-induced
clustered DNA lesions. The … about the repair and biological effects of clustered DSBs …

… more complex and even clustered DNA double-strand breaks (… Here, we review the specific
cellular DNA damage responses (… DSB repair pathways through the activation of DNA end …

… Since emphasis on this review is given on the radiation-induced DNA damage, the reader
… of clustered DNA damage are considered a very heavy load for the cellular repair systems, …

… clustered DSBs, in contrast to complex DNA lesions. It … DNA lesions may delay the speed
of overall DNA repair because complex DNA lesions likely disrupt the recruitment of DNA repair …

… of the yield and spectra of radiation-induced clustered DNA damage that were revealed …
biochemical consequences of clustered lesions including their repair and mutagenic potential. …

… the damage complexity of clustered DNA damage, wherein damage-containing genomic DNA
… was established to analyze the radiation-induced clustered DNA damage in the genomic …

… DNA. We also evaluated the potential biological consequences of many of the radiation-induced
DNA lesions. In … Single stranded DNA was chosen so lesion bypass and mutagenesis …

… to characterize direct radiation-induced DNA damage as one … DNA damage and mutagenesis.
Other groups have made great strides in modeling such DNA repair, particularly the repair …

… clustered lesions that are responsible for mutagenic, genotoxic, and … clustered DNA damage
consisting of an SSB and an adjacent BD comprises 90% of the total clustered DNA lesions …