Genetics of human primary hypertension: focus on hormonal mechanisms

W Manosroi, GH Williams - Endocrine reviews, 2019 - academic.oup.com
hypertensive phenotypes had a substantial endocrine component. In conclusion, primary
hypertension … to determine the utility of genetics in the treatment of hypertension. However, to …

Genetics and genomics of pulmonary arterial hypertension

NW Morrell, MA Aldred, WK Chung… - European …, 2019 - Eur Respiratory Soc
genetic and genomics of pulmonary arterial hypertension (… genetic cause for their condition
and should be classified as heritable PAH (HPAH). Here, we summarise the known genetic

Genomics of hypertension: the road to precision medicine

S Padmanabhan, AF Dominiczak - Nature Reviews Cardiology, 2021 - nature.com
… history of hypertension 20 . The familial risk of hypertension is likely to be due to genetic
factors because statistical modelling showed that the risk of hypertension in grandchildren …

Pharmacogenomics and hypertension: current insights

GH Oliveira-Paula, SC Pereira… - Pharmacogenomics …, 2019 - Taylor & Francis
… provide valuable genetic information for hypertension pharmacogenomics research… genetic
markers, a systematic review and meta-analysis involving the recent studies on hypertension

Molecular genetic framework underlying pulmonary arterial hypertension

L Southgate, RD Machado, S Gräf… - Nature Reviews …, 2020 - nature.com
… and genetic modifying factors. In this Review, we discuss the genetic aetiology of PAH
and the factors that might influence screening and treatment strategies in the future. …

… of primary aldosteronism: a position statement and consensus of the Working Group on Endocrine Hypertension of The European Society of Hypertension

P Mulatero, S Monticone, J Deinum, L Amar… - … of hypertension, 2020 - journals.lww.com
… aldosteronism in the general population with hypertension [5] , some … of genetic testing and
the unequivocal benefits of an early diagnosis of a familial disorder, we suggest that genetic

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

V Steinthorsdottir, R McGinnis, NO Williams… - Nature …, 2020 - nature.com
… risk of essential hypertension, coronary artery disease … genetic predisposition to hypertension
is a major risk factor for preeclampsia. However, comparison with gestational hypertension

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

CJ Rhodes, K Batai, M Bleda, M Haimel… - The Lancet …, 2019 - thelancet.com
genetic variants cause pulmonary arterial hypertension, but the contribution of common
genetic … We tested for genome-wide association for pulmonary arterial hypertension in large …

Pathophysiology of hypertension: the mosaic theory and beyond

DG Harrison, TM Coffman, CS Wilcox - Circulation research, 2021 - Am Heart Assoc
… The elusive nature of primary hypertension and the precise … hypertension and in models of
experimental hypertension, … vasoconstrictor and pro-hypertensive agent isolated from renal …

Future of hypertension: The need for transformation

VJ Dzau, CA Balatbat - Hypertension, 2019 - Am Heart Assoc
… research efforts focused on hypertension, we have seen slow progress in global control of
hypertension. Transformation is urgently needed to reduce the global burden of hypertension. …