All-trans Retinoic Acid as a Versatile Cytosolic Signal Modulator Mediated by CRABP1

I Nagpal, LN Wei - International journal of molecular sciences, 2019 - mdpi.com
… reflected by the activation of extracellular signal-regulated kinases 1/2 (ERK1/2… kinase [76,77].
Once activated, RAF phosphorylates mitogen-activated protein kinase MAPK-ERK kinase

A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1

SW Park, J Nhieu, SD Persaud, MC Miller, Y Xia… - Scientific reports, 2019 - nature.com
kinases including p38 mitogen activated protein kinase (MAPK), PI3 kinase, and
extracellular-signal-regulated kinase 1/… determined that cellular retinoic acid binding protein 1 …

CRABP1 in non-canonical activities of retinoic acid in health and diseases

J Nhieu, YL Lin, LN Wei - Nutrients, 2022 - mdpi.com
… The MAPK kinase signaling cascade is comprised of Ras GTPase which activates RAF, …
mitogen-activated protein kinase kinase (MEK), and then extracellular-signal-regulated kinase (…

Retinoic receptor signaling regulates hypertrophic chondrocyte-specific gene expression

T Shimo, E Koyama, T Okui, M Masui, Y Kunisada… - in vivo, 2019 - iv.iiarjournals.org
… and phosphorylated mitogen-activated protein kinase (MAPK). … , the retinoic acid receptors
(RARα, -β and-γ) and the retinoid X … of phosphorylated extracellular signal regulated-kinases (…

[HTML][HTML] … enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid …

A Rashid, X Duan, F Gao, M Yang, A Yen - Oncotarget, 2020 - ncbi.nlm.nih.gov
… However, other signaling pathways, particularly mitogen-activated protein kinase (MAPK),
have been found to be necessary for RAR and RXR to transcriptionally activate and …

Roscovitine enhances All-trans retinoic acid (ATRA)-induced leukemia cell differentiation: Novel effects on signaling molecules for a putative Cdk2 inhibitor

A Rashid, X Duan, F Gao, M Yang, A Yen - Cellular Signalling, 2020 - Elsevier
… functional markers of ATRA-induced differentiation, we explored its effects on activation of
MAP kinase cascade. Roscovitine enhanced ATRA-induced signalsome activation events. In …

ERK MAP Kinase Signaling Regulates RAR Signaling to Confer Retinoid Resistance on Breast Cancer Cells

A Hirota, JE Clément, S Tanikawa, T Nonoyama… - Cancers, 2022 - mdpi.com
… Among potential anticancer drugs considered promising in breast cancer treatment are
retinoids that act mainly through nuclear retinoic acid receptors (RARs). Clinical trials, however, …

Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells

SM Kim, T Yokoyama, D Ng, F Ulu, Y Yamazaki - PLoS One, 2019 - journals.plos.org
mitogen-activated protein kinase (MAPK) [29], protein kinase C (PKC) [30] and AKT pathways
[31]. Particularly, the MAPK pathways, including the extracellular signal-regulated kinase (…

Targeting Cellular Retinoic Acid Binding Protein 1 to Modulate Non-Canonical Retinoic Acid Signaling

J Nhieu - 2023 - search.proquest.com
mitogen-activated protein kinase kinase (MEK), and then extracellular-signal-regulated
kinase … , ie, extracellular signal-regulated kinase (Erk) and calcium (Ca2+) calmodulin-dependent …

Retinoic acid-induced regulation of inflammatory pathways is a potential sepsis treatment

HH Dolin, JH Franco, X Chen, ZK Pan - Infection and Immunity, 2023 - Am Soc Microbiol
… other proinflammatory pathways such as mitogen-activated protein kinase (MAPK) (14). NF-…
uses extracellular signal-regulated kinase 1/2 (ERK1/2), p38, and c-Jun N-terminal kinases (…