… daily dose ranges between 10 to 80 mg, depending on initial LDL blood levels. After oral …
Atorvastatin is known to alter the in vitro expression of SLC22A1 and in rats co-administered …

… Atorvastatin is affected less severely by the SLCO1B1 gene … , cyclosporin, digoxin, gemfibrozil,
ketoconazole, and rifampin … 521T>C genotype) correlates with an attenuated effect on …

… SLCO1B1 and ABCC2 and their health status. Genotyping of … LC-MS/MS analysis of statins
and rifampicin. The remaining … genotypes (521 T > C) on plasma concentrations of fluvastatin …

… associated with changes in drug concentrations and effects (… between rosuvastatin and
rifampicin demonstrated that … the occurrence of ADRs were SLCO1B1 (all statins), ABCG2 (…

… 521T>C variant increases plasma concentrations of several … In this study, N151S was shown
to be benign: it did not alter … plasma concentrations might be even greater for other statins. …

… substrates other than atorvastatin to determine rifampicin IC 50 … OATP1B1 shows substantial
IC 50 value changes (up to 177-… of rifampicin unbound concentrations in liver and plasma. …

… statins in decreasing LDL-C plasma levels has been proven. … between atorvastatin with
SLCO1B1 rs4149056 (Santos … 521T>C genotype and myopathy for personalisation of statin …

… SLCO1B1*14 has also been associated with a decreased AUC of atorvastatin27 and c.463C>A
with decreased plasma concentrations of rifampin.29 …

… 521T>C are in an … of SLCO1B1 pharmacogenetics found that dysfunction of the protein-transporter
leads to reduced absorption by the liver cells, the increasing of plasma concentrations …

… Conversely, if the changes caused by genetic variations in … 521T>C reduces the OATP1B1
activity for certain substrates. … active uptake of atorvastatin in the Caucasian SLCO1B1 c.…