Glycolaldehyde, an advanced glycation end products precursor, induces apoptosis via ROS-mediated mitochondrial dysfunction in renal mesangial cells

MJ Gu, JY Hyon, HW Lee, EH Han, Y Kim, YS Cha… - Antioxidants, 2022 - mdpi.com
… by interacting with AGEs that damage cells, leading to target … via the kidneys, which are
essential organs for AGE filtration [… with NAC, an ROS scavenger. This suggests that GA and GA-…

Interplay among oxidative stress, methylglyoxal pathway and S-glutathionylation

L de Bari, A Scirè, C Minnelli, L Cianfruglia… - Antioxidants, 2020 - mdpi.com
… the scavenging of ROS as well as of the reactive 2-oxoaldehydes … oxidation is fundamental
to block further damage on protein … is important for ROS-mediated signaling pathways. …

Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications, and other age-related diseases

CG Schalkwijk, CDA Stehouwer - Physiological reviews, 2020 - journals.physiology.org
… intermediates of glycolysis induce damage to the vasculature and … itself induce insulin
resistance and β-cell dysfunction, and … Because GSH is also an essential cellular cofactor for Glo1 …

[HTML][HTML] Metformin inhibits methylglyoxal-induced retinal pigment epithelial cell death and retinopathy via AMPK-dependent mechanisms: reversing mitochondrial …

P Sekar, G Hsiao, SH Hsu, DY Huang, WW Lin… - Redox Biology, 2023 - Elsevier
… In vital dye-induced damage of RPE and in retinitis pigmentosa … Cytosolic ROS-mediated
autophagy and subsequent … protection, we exclude the scavenger action of metformin as …

[PDF][PDF] Interplay among Oxidative Stress, Methylglyoxal Pathway and S-Glutathionylation. Antioxidants 2021, 10, 19

L de Bari, A Scirè, C Minnelli, L Cianfruglia… - 2020 - academia.edu
… (GSH), required for the scavenging of ROS as well as of the … oxidation is fundamental to
block further damage on protein … production is important for ROS-mediated signaling pathways…

Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells

X Zhang, A Rodriguez-Niño, DO Pastene, P Pallavi… - Scientific Reports, 2021 - nature.com
… changes include vascular damage, insulin resistance and low … to DNA damage and cellular
stress and plays a critical role in … In keeping with carnosine’s ability to scavenge reactive …

Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer

J Bellier, MJ Nokin, E Lardé, P Karoyan… - Diabetes research and …, 2019 - Elsevier
… favor cancer cell proliferation, migration and resistance to … , AGEs can generate substantial
cellular damage. All proteins … major alterations of fundamental cellular processes such as …

mpsmpRole of methylglyoxal and redox homeostasis in microbe-mediated stress mitigation in plants

S Garai, B Bhowal, M Gupta, S Sopory… - Plant Science, 2023 - Elsevier
important mechanisms of stress alleviation. Further, we also examine the microbial mechanisms
of resistance … protect the organism from ROS-mediated extensive oxidative damage (Fig. …

[HTML][HTML] Alu antisense RNA ameliorates methylglyoxal-induced human lens epithelial cell apoptosis by enhancing antioxidant defense

PY Wu, N Ji, CG Wu, XD Wang, X Liu… - International Journal …, 2023 - ncbi.nlm.nih.gov
… Although the transfection efficiency of Lipofectamine 2000 was relatively high, this … damage
and increased proliferation in HLECs. It has been reported that SINE RNAs have important

Glyoxal in Foods: Formation, Metabolism, Health Hazards, and Its Control Strategies

M Zhang, C Huang, J Ou, F Liu, S Ou… - Journal of Agricultural …, 2024 - ACS Publications
… by scholars focuses mainly on methylglyoxal and acrolein. This … pathway targets and
ROS-mediated biomolecules by blocking … inhibitors that are more resistant to digestion should also …