Anti-Glucotoxicity Effect of Phytoconstituents via Inhibiting MGO-AGEs Formation and Breaking MGO-AGEs

N Yadav, JD Palkhede, SY Kim - International Journal of Molecular …, 2023 - mdpi.com
… and methods of formation of methylglyoxal-advanced glycation end … in wound healing, tissue
regeneration, insulin resistance, and … MGO blocked the ROS-mediated Akt/mTOR signaling …

Beyond glucose: The dual assault of oxidative and ER stress in diabetic disorders

TF Roohi, S Faizan, ZA Parray, MDAI Baig… - High Blood Pressure & …, 2023 - Springer
… We explore ROS-mediated signaling pathways, which trigger β-cell dysfunction, insulin
resistance, … Moreover, ROS promote the generation of glucose metabolite methylglyoxal, which …

Silicon in mitigation of abiotic stress-induced oxidative damage in plants

MG Mostofa, MM Rahman, MMU Ansary… - Critical Reviews in …, 2021 - Taylor & Francis
… support the cells to overcome ROS-mediated damage. … to improve the ROS-scavenging
capacity under salt stress by … tolerance, manipulating the Si-uptake potential of important

Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of developing diabetes and in drug-naïve T2D

L La Sala, S Mrakic-Sposta, E Tagliabue… - Cardiovascular …, 2019 - Springer
damage occurring in plasma and the relative effectiveness of … to be an important trigger
for insulin resistance, although … The main role of SOD2 is to scavenge superoxide radicals, …

Oxidative Stress‐Mediated Blood‐Brain Barrier (BBB) Disruption in Neurological Diseases

K Song, Y Li, H Zhang, N An, Y Wei… - … and cellular …, 2020 - Wiley Online Library
… in decreased transepithelial electric resistance (TEER) and … AMPK is also known to be
involved in critical cell stress … Therefore, methylglyoxal damage to proteins can be mediated …

Unique thiol metabolism in trypanosomatids: Redox homeostasis and drug resistance

V Ali, S Behera, A Nawaz, A Equbal, K Pandey - Advances in Parasitology, 2022 - Elsevier
resistance. Redox-active biomolecules are the endogenous substances in organisms, which
play important … In the present review, the suitability of trypanothione and other essential thiol …

[PDF][PDF] Abiotic stress and reactive oxygen species: Generation, signaling, and defense mechanisms. antioxidants 2021, 10, 277

S Sachdev, SA Ansari, MI Ansari, M Fujita… - 2021 - academia.edu
… , ROS accumulation, and methylglyoxal content that induce oxidative … tolerance [7]. The
spatio-temporal production of ROS is a critical factor that determines the ROS mediated cellular

Melatonin enhanced the heavy metal-stress tolerance of pepper by mitigating the oxidative damage and reducing the heavy metal accumulation

MA Altaf, Y Hao, H Shu, MA Mumtaz, S Cheng… - Journal of Hazardous …, 2023 - Elsevier
… is crucial for improved resistance to HMs toxicity. … , glyoxalase defense system, and
methylglyoxal contents in pepper … mechanism and prevent ROS-mediated damage of thylakoid …

Approaches to enhancing antioxidant defense in plants

M Fujita, M Hasanuzzaman - Antioxidants, 2022 - mdpi.com
… and causing significant damage to essential cellular components such … However, the exact
pathways of ROS-mediated stress … be useful in directing efforts to increase cold tolerance [15]. …

Antiglycative activity and RAGE expression in Rett syndrome

V Cordone, A Pecorelli, M Benedusi, S Santini Jr… - Cells, 2019 - mdpi.com
… In order to evaluate the cellular susceptibility to methylglyoxal … that in RTT cells, the glyoxalase
scavenging system is unable to … damage were detected when we compared CTR and RTT …