[HTML][HTML] Novel molecular cues for dental defects in hypophosphatasia

H Melms, M Herrmann, K Förstner, R Bharti… - Experimental Cell …, 2020 - Elsevier
… Using this in vitro model of TNAP deficiency in DPSCs and … Network analysis for protein
interaction of downregulated genes in … The complexity of neuron-specific signal transduction in …

TNAP as a therapeutic target for cardiovascular calcification: a discussion of its pleiotropic functions in the body

C Goettsch, A Strzelecka-Kiliszek… - Cardiovascular …, 2022 - academic.oup.com
… their brain, a molecule of the transsulfuration pathway that is … –168 a role in signal transduction
through interaction with PrPc, … Analyses of post-mortem AD brains showed an increase in …

TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors

B Arnò, F Galli, U Roostalu, BM Aldeiri… - Journal of cell …, 2019 - journals.biologists.com
analysed expressed TNAP in normal heart (TNAP/… molecular mechanism described here,
TNAP may also indirectly affect the activity of numerous phosphorylation-dependent pathways

[PDF][PDF] Integrating Bioinformatics To Identify Potential Cytokines ALPL/TNAP In Children With Spastic Cerebral Palsy

X Wang, C Gao, H Zhong, X Kong, R Qiao, H Zhang… - 2021 - scholar.archive.org
… Through proteomic and transcriptome analysis and development of a PPI network, we
identi ed molecules closely related to CP and further analyzed whether TNAP, the expression …

Brain endothelial cell tissue-nonspecific alkaline phosphatase (TNAP) activity promotes maintenance of barrier integrity via the ROCK pathway

DC Nwafor, AL Brichacek, W Wang, N Bidwai, CL Lilly… - bioRxiv, 2021 - biorxiv.org
TNAP at the brain endothelium and examined the molecular and cellular pathways targeted
by TNAP… In addition, morphological analyses of endothelial TNAP conditional knockout cell …

Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities

MA Ortega, D De Leon-Oliva, MJ Gimeno-Longas… - Biomolecules, 2024 - mdpi.com
signal transduction from the receptor to the nucleus within the cell when the type I receptor is
activated. The BMP-2/Smad signaling pathwayTNAP breaks down excess extracellular PPi …

Genes and Gene Networks Regulating Mineralization

IM Shapiro, WJ Landis - … of Mineralization of Vertebrate Skeletal and …, 2024 - Springer
… latent transcription factors involved in signal transduction. … illustrations, analysis of gene
regulatory networks has … stated that “the SOX molecular network is likely far more sophisticated …

TNAP—a potential cytokine in the cerebral inflammation in spastic cerebral palsy

XK Wang, C Gao, HQ Zhong, XY Kong… - Frontiers in Molecular …, 2022 - frontiersin.org
… profiling analysis was applied to analyze expressive levels of … In all, based on the analysis
of the correlation between TNAP … blood TNAP, we suggest that the downregulation of TNAP

Tissue-Nonspecific alkaline Phosphatase—A gatekeeper of physiological conditions in health and a modulator of biological environments in disease

D Liedtke, C Hofmann, F Jakob, E Klopocki, S Graser - Biomolecules, 2020 - mdpi.com
molecular network analysis using the network of signal transduction of a pyramidal neuron
and information on TNAP … the desensitization of the signal transmission at the neuromuscular …

HLA-B27–mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis

CH Liu, S Raj, CH Chen, KH Hung… - The Journal of …, 2019 - Am Soc Clin Investig
… To summarize, the analyses of Taiwanese and British cohorts validated our experimental …
We then investigated the molecules involved in the 3 main UPR pathways, the PERK/activating …