Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues

Y Tan, WF Flynn, S Sivajothi, D Luo, SB Bozal… - Nature cell …, 2022 - nature.com
… The presence of basophils and neutrophils (arrow) indicate … –receptor analysis to identify
specific interactions involving Prv… T Reg cell regulatory function were altered between Ctrl and …

Decoding human fetal liver haematopoiesis

DM Popescu, RA Botting, E Stephenson, K Green… - Nature, 2019 - nature.com
… In this study, we use single-cell transcriptomics to map the … Neutrophils, basophils and
eosinophils were not detected, … flow cytometry (BD FACS Symphony). Colony output was …

[HTML][HTML] Defective Sec61α1 underlies a novel cause of autosomal dominant severe congenital neutropenia

E Van Nieuwenhove, JS Barber, J Neumann… - Journal of Allergy and …, 2020 - Elsevier
… stress response, with single-cell analysis of primary bone marrow … Here, we identify a new
SEC61A1 mutation with autosomal … of V67 forms hydrophobic interactions with TM5 and TM10 …

[PDF][PDF] LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma

C Gur, SY Wang, F Sheban, M Zada, B Li, F Kharouf… - Cell, 2022 - cell.com
… number of ligand-receptor interactions with the skin immune … , we conducted a single-cell
analysis of 6 patients with a … scleroderma (morphea), and identified a similar perturbation of the …

Amphiregulin couples IL1RL1+ regulatory T cells and cancer-associated fibroblasts to impede antitumor immunity

R Sun, H Zhao, DS Gao, A Ni, H Li, L Chen, X Lu… - Science …, 2023 - science.org
… We used paired single-cell RNA and T cell receptor (TCR) … We identified regulons of interest
that exhibit differential … Although AREG produced by mast cells and basophils have been …

[PDF][PDF] Defective Sec61a1 underlies a novel cause of autosomal dominant severe congenital neutropenia

MD Erika Van Nieuwenhove, JS Barber, J Neumann… - Allergy, 2020 - academia.edu
… Results: We identified a novel de novo missense mutation in … stress response, with single-cell
analysis of primary bone … level of 0.287 3 109/L, and basophil level of 0.096 3 x109/L. The …

Effects of STAT3 gain of function on myeloid cells in human peripheral blood mononuclear cells

D Dixon - 2020 - theses.ncl.ac.uk
… findings: Single cell RNA sequencing of PBMCs identified 17 … cells as well as identifying
increased expression of glycolytic … displayed altered glycolytic characteristics as well as altered

[HTML][HTML] Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

D Mathew, JR Giles, AE Baxter, AR Greenplate, JE Wu… - BioRxiv, 2020 - ncbi.nlm.nih.gov
… expression of sixteen major CD4 T cell markers to delineate the populations identified in
each cluster (Figure 3I). This analysis identified an increase in Cluster 3 and 4 cells in COVID-…

Molecular features of T lymphocytes in the immune response against breast cancer

A Losurdo - 2021 - oro.open.ac.uk
… to do so we applied high-dimensional single-cell profiling to dozens of … We initially took
advantage of publicly available data from the single-cell RNA-seq analyses of 8 breast cancers …

T lymphocytes and testicular immunity: a new insight into immune regulation in testes

J Gong, Q Zeng, D Yu, YG Duan - International journal of molecular …, 2020 - mdpi.com
… Different T cell subsets have been identified in mammalian … CD4 + T cells play an orchestral
role. T cells function directly in a … and single-cell sequencing, allows us to analyze samples …