Mapping breast cancer microenvironment through single-cell omics

Z Tan, C Kan, M Sun, F Yang, M Wong… - Frontiers in …, 2022 - frontiersin.org
breast cancer microenvironment, focusing on scRNA-seq studies and analyzing heterogeneity
and spatial location of different … between TCA cycle and phenotypic states of T cells (32), …

Single-cell profiling to explore immunological heterogeneity of tumor microenvironment in breast cancer

X Yuan, J Wang, Y Huang, D Shangguan… - Frontiers in …, 2021 - frontiersin.org
Cancer Center drew a single-cell atlas of diverse immune phenotypes of breast cancer
samples and found the immune … of the transcriptional map of the tumor microenvironment. This …

A comprehensive single-cell map of T cell exhaustion-associated immune environments in human breast cancer

S Tietscher, J Wagner, T Anzeneder… - Nature …, 2023 - nature.com
single-cell analysis of tumor microenvironments at the … of cell type abundances, cellular
phenotypes, and cell-cell … by different immune escape mechanisms—avoidance of tumor-…

[HTML][HTML] A single-cell atlas of the tumor and immune ecosystem of human breast cancer

J Wagner, MA Rapsomaniki, S Chevrier, T Anzeneder… - Cell, 2019 - cell.com
… This large-scale, single-cell atlas deepens our understanding of breast tumorbreast
cancer-free individuals. Our data revealed vast phenotypic diversity among tumor and immune

Single-cell and spatial transcriptome analyses revealed cell heterogeneity and immune environment alternations in metastatic axillary lymph nodes in breast cancer

X Mao, D Zhou, K Lin, B Zhang, J Gao, F Ling… - Cancer Immunology …, 2023 - Springer
tumor microenvironments as well as the systematic immune … Comparing myeloid cells across
different tissues (Fig. 2A and … 2E, Table S4) and mapping them to the expression profiles …

Cellular heterogeneity map of diverse immune and stromal phenotypes within breast tumor microenvironment

Y Li, Z Chen, L Wu, J Ye, W Tao - PeerJ, 2020 - peerj.com
… We created a uniquecellular map for the diverse heterogeneity of immune and stromal
phenotypes within the breast tumor microenvironment. This map may lead to potential therapeutic …

A single-cell transcriptomic landscape of innate and adaptive intratumoral immunity in triple negative breast cancer during chemo-and immunotherapies

L Carpen, P Falvo, S Orecchioni, G Mitola, R Hillje… - Cell Death …, 2022 - nature.com
… of the immune landscape in the tumor microenvironment (… cellular populations, phenotypes
and transitional states. This … the two different types of chemistry used during the single cell

Comprehensive description of the current breast cancer microenvironment advancements via single-cell analysis

X Yan, Y Xie, F Yang, Y Hua, T Zeng, C Sun… - … & Clinical Cancer …, 2021 - Springer
… the recent progress in single-cell characterization of breast tumor ecosystems, and summarized
the phenotypic diversity of intra-tumoral … Flow chart of experimental design and analysis …

A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer

A Bassez, H Vos, L Van Dyck, G Floris, I Arijs… - Nature medicine, 2021 - nature.com
… Collectively, our data identify various immunophenotypes … , we subclustered the 7,952
myeloid cells into 10 phenotypes, … -naive BC microenvironments at single-cell resolution 36,37,…

Insights gained from single-cell analysis of immune cells in the tumor microenvironment

X Ren, L Zhang, Y Zhang, Z Li… - Annual review of …, 2021 - annualreviews.org
… the immune interplay of these diverse cell types in the tumor … of the phenotypes and functions
of tumor-infiltrating immune cells … The application of scRNA-seq to simultaneously chart the …