… We discuss many regulatory mechanisms of sirtuins because they provide important insights
into the functions of these proteins. Interesting questions that arise include whether different …

… We further highlight the recent development of small-molecule modulators that provide
additional biological insight into SIRT6 functions and offer therapeutic approaches to manage …

… that sirtuins have a relevant role in DNA repair. Notably, … the sirtuins directly to the DNA repair
were taken into account, … that this sirtuin cannot collaborate indirectly or that its participation …

… that sirtuins appear to be conserved from yeast to mammals, however the complexity of their
function … modulators of the sirtuins have yielded key insights into the pathophysiological …

… diseases in the organisms ranging from yeast to mammals. SIRT protein exhibits two …
insight into the biochemical and nutritional aspect of each member of SIRT family along with its …

… Sirtuins are evolutionarily conserved in all domains of life, and, based … their sequence
similarity, they are classified into five classes (I–IV and U) (Figure 2). The seven mammalian sirtuin …

… stimuli is less developed in SIRT1 knockout animals compared with wild-type animals. …
Previous studies have offered considerable insight into the substrate-specific deacylase ability of …

… Here, we focus on the developments in the epigenetic roles of mammalian sirtuins in the …
the seven mammalian sirtuins. This highlights the important biological functions of sirtuins, yet …

… mammalian sirtuin family, also in context of its connection with oxidative stress, it is known that
all of the mammalian sirtuins … , with particular emphasis on sirtuins located in mitochondria …

… In this review, we provide an up-to-date overview of sirtuin biology and pharmacology. We
examine … of lifespan, mammalian sirtuins are involved in a wide range of biological functions. …