… delineates the role of each sirtuin isoform in NDs from a … up-to-date overview of sirtuin
modulators and their potential use as … Sirtuins have important roles to play in the mammalian …

… insight into these connections and omics data obtained from long-lived species may yield
new insights because their metabolism appears distinct from … seven mammalian sirtuins found …

… Mammals have seven distinct members of the SIRT family (SIRT1-7), which play … of their
roles during infection. This illustrates the need for further research for gaining deeper insight into …

… are only four known lipoylated multicomponent enzymatic complexes in mammals: pyruvate
… the function of SIRT4 as a tumor suppressor and provide mechanistic insights into the SIRT4 …

… It was found that insect sirtuins are significantly different from mammalian ones. Research
conducted on Caenorhabditis elegans confirmed the presence of the SIR2 (Sir-2.1) ortholog, …

… a mounting interest in the development of sirtuin activators. The availability of … sirtuin
activators and provide comprehensive coverage of the role that structural biology played in their …

… http://dx.doi.org/10.1042/CS20120190 PMID: 23075334 [25] Budayeva, HG; Rowland, EA;
Cristea, IM Intricate roles of mammalian sirtuins in defense against viral pathogens. J. Virol., …

… In this context, data generated over the last decade have uncovered mammalian sirtuins
as … In this section we discuss the role of sirtuins on immunometabolism imbalance and its …

… way to mammalian SIRT3. Our results indicate that there are at least eight sirtuin paralogs
among … Sirtuins in mammals: insights into their biological function. Biochem J. 404:1–13. …

… The U class sirtuins have only been observed in bacteria. Although subcellular localization
and functions are different, mammalian sirtuins have different divisions of labor from …