… and development of small molecule modulators for PCDs. … cancers, ischemia-reperfusion
injury, and autoimmune disorders, which are caused by dysfunction of the regulated cell death …

… modulator of the mPTP, which makes it a key target for circumventing necrotic cell death [305]. …
] and colleagues has identified classes of small molecules that are able to selectively bind …

… Accordingly, it has been documented that the modulation of key molecules of the canonical
… regulated cell death modes resembling some features of passive necrosis in cardiac damage …

… inhibitor; H: cardiac I/R rats treated with high dose of cell death inhibitor. I/R ischemia/reperfusion
injury, RIPK receptor interacting protein kinases, MLKL mixed lineage kinase domain-…

… PKM2 is a regulatory protein with complex functions and plays a regulatory role in tumor
and inflammatory diseases. Therefore, we examined the regulatory effect of ISB on PKM2. We …

… or prevent necroptotic cell death by enabling membrane remodeling. Small molecule
inhibitors of … 1 or NF-κB essential modulator. Complex IIb consists of RIPK1, RIPK3, FAS-associated …

… Pyroptosis is another type of regulated cell death, characterized by cell membrane pore …
induced into death by Shigella flexneri infection [7]. In 2001, this form of regulated cell death was …

… This reduction in cell death correlated with increased … Since mTOR is a strong modulator of
autophagy [39], inhibition of … Last but not least, it is challenging to mimic the small molecule-…

… ultimately mediates cellular death and microvascular collapse. … promoting MIRI via the
modulation of neutrophil infiltration [… Another study regarding small molecule agonists of formyl …

… I/R injury. MQC includes mitochondrial fission, mitochondrial fusion, mitophagy and
mitochondria-dependent cell death. … In this review, we summarize the regulatory mechanisms and …