The State-of-the-Art Mechanisms and Antitumor Effects of Somatostatin in Colorectal Cancer: A Review

A Kasprzak, A Geltz - Biomedicines, 2024 - mdpi.com
… Somatostatin, a somatotropin release inhibiting factor (SST, … distributed multifunctional
cyclic peptide produced by cells … with the low degree of tumor differentiation, lymph node …

Somatostatin and its receptor system in colorectal cancer

A Kasprzak - Biomedicines, 2021 - mdpi.com
… as the somatotropin release-inhibiting factor/hormone (SRIF, SRIH) or … Thus, SST inhibits
glucagon secretion at low and high glucose … with tumor stage and lymph node metastasis [118]. …

Receptors for Targeting Gastrointestinal Tract Cancer

T Pant, N Aware, PV Devarajan, R Jain… - … Drug Delivery by …, 2019 - Springer
… , where it is associated with increased lymph node metastasis, … (SS-14) that inhibited secretion
of the growth hormone in rat … (i) the extracellular domain containing 519 aa and consisting …

Neuromodulation of bone: Role of different peptides and their interactions

X Wang, J Xu, Q Kang - Molecular Medicine Reports, 2021 - spandidos-publications.com
… -insulin-like growth factor 1 (IGF-1; a growth hormone … domain protein 2 activity (a FERM
domain-containing guanine … tissue as it contains no blood vessels or lymphatics and is not …

Somatostatin and Somatostatin Receptors in Tumour Biology

U Kumar - International Journal of Molecular Sciences, 2023 - mdpi.com
peptide hormone-based therapy in various types of tumour treatments. Somatostatin (SST),
a growth hormone (GH)-inhibitory peptide, inhibitslow dose of glucocorticoids and inhibited

Peptide-based strategies for targeted tumor treatment and imaging

A Ayo, P Laakkonen - Pharmaceutics, 2021 - mdpi.com
… ; the non-CendR domain containing peptide (CRGDGGPDC) … the inhibition of growth
hormone secretion and inhibition of … Octreotide (SMS 201-995), an 8-mer cyclic peptide derived

Generation of Long-acting Growth Hormone Receptor Antagonists

Y Wang - 2020 - researchspace.auckland.ac.nz
… The GH receptor (GHR) antagonist, B2036, effectively inhibits GH … coli when expressed
at low temperature. … adaptor protein Shc (src homology 2 domain containing transforming …

Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide

AC Mirando, A Patil, CI Rafie, BJ Christmas… - …, 2020 - Taylor & Francis
… T cells (Tregs), and low levels of TAMs are all generally … the accidental capture of axillary
lymph nodes as well. The … factor inhibition effects of AXT201 suggested that the peptide

[PDF][PDF] A Flippase-Like Domain-Containing Protein From Deltaproteobacteria Bacterium (Marine Sediment Metagenome) Has Anti-prostate Cancer Effects

M Danaeifar - Avicenna Journal of Medical Biochemistry, 2022 - ajmb.umsha.ac.ir
… metastasis in other organs such as bones and lymph nodes (3). In the … The native structure
of the growth hormone-releasing … is not a matrix metalloproteinase inhibitor or a mutagenic …

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

X Jiang, J Wang, X Deng, F Xiong, J Ge, B Xiang, X Wu… - Molecular cancer, 2019 - Springer
… escape, including the low immunogenicity of tumor cells, … widely distributed in the peripheral
blood, lymph nodes, spleen, … and reactive oxygen species to inhibit the activity of immune …